HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: PYR1 (P27708)
Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
Gene: CAD

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0033574 - response to testosterone GO:0042594 - response to starvation
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 2225
+	Hs
		610253 CBL_HUMAN (1-906): 0: 917: 100.00		CPSM_HUMAN (2-1448): 0: 1504: 50.61
+	Sc
		424519 SEC31_YEAST (554-901): 1.04e-09: 64.6: 8.27		PYR1_YEAST (1-2223): 0: 2271: 49.41
+	Hs
		610419 CBL_HUMAN (1-906): 0: 917: 100.00		DPYL2_HUMAN (1397-1915): 9.65e-161: 510: 18.29
+	Hs
		610398 CBL_HUMAN (1-906): 0: 917: 100.00		DPYL1_HUMAN (1397-1915): 3.53e-160: 508: 17.78
+	Hs
		610399 CBL_HUMAN (1-906): 0: 917: 100.00		DPYL3_HUMAN (1397-1915): 5.83e-160: 507: 18.15