HitPredict

Interactor 1: NR4A1 (P22736)
Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3)
Gene: NR4A1

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28622293
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 598 Hs			1 628
+	Hs
		370843 ESR1_HUMAN (61-592): 2.41e-97: 311: 22.79		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		1270069 ESR2_HUMAN (128-592): 7.55e-97: 307: 24.07		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		277936 NR4A1_HUMAN (1-598): 8.52e-140: 420: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278072 NR1H3_HUMAN (178-591): 7.99e-114: 348: 29.29		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278228 NR4A1_HUMAN (1-598): 8.52e-140: 420: 100.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278004 NR1H2_HUMAN (181-592): 8.61e-104: 323: 23.53		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277974 HNF4A_HUMAN (223-597): 2.07e-100: 314: 23.81		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277875 ESR1_HUMAN (61-592): 2.41e-97: 311: 22.79		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277964 PPARG_HUMAN (120-594): 8.32e-99: 311: 21.55		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278138 ESR2_HUMAN (128-592): 7.55e-97: 307: 24.07		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277876 GCR_HUMAN (21-597): 6.09e-93: 304: 22.09		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278206 ESR1_HUMAN (61-592): 2.41e-97: 311: 22.79		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278312 ESR2_HUMAN (128-592): 7.55e-97: 307: 24.07		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278207 GCR_HUMAN (21-597): 6.09e-93: 304: 22.09		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		782594 HNF4A_HUMAN (223-597): 2.07e-100: 314: 23.81		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		510028 ERR1_HUMAN (267-538): 6.75e-38: 147: 34.69		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71