Protein: PSB4
Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3) (Proteasome subunit beta-7) (beta-7)

Gene: PSB4, PSMB4
Organism: Homo sapiens
Interactions: 207
UniProt ID: P28070

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0001530 - lipopolysaccharide binding
GO:0002862 - negative regulation of inflammatory response to antigenic stimulus
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

700947

PSB7
Proteasome subunit beta type-7

12

19

Small-scale

0.977

High

681108

PSA2
Proteasome subunit alpha type-2

8

20

Small-scale

0.970

High

633605

PSB1
Proteasome subunit beta type-1

8

20

High-throughput

0.966

High

700976

POMP
Proteasome maturation protein

5

15

Small-scale

0.927

High

680779

PSA1
Proteasome subunit alpha type-1

5

20

High-throughput

0.922

High

681577

PSA4
Proteasome subunit alpha type-4

5

20

Small-scale

0.922

High

700557

PSA5
Proteasome subunit alpha type-5

5

20

Small-scale

0.922

High

165268

PSA7
Proteasome subunit alpha type-7

5

20

Small-scale

0.919

High

700850

PSB2
Proteasome subunit beta type-2

5

19

Small-scale

0.919

High

681261

PSA3
Proteasome subunit alpha type-3

4

20

High-throughput

0.910

High

700837

PSB5
Proteasome subunit beta type-5

4

19

Small-scale

0.902

High

700849

PSB3
Proteasome subunit beta type-3

4

19

Small-scale

0.897

High

700873

PSME1
Proteasome activator complex subunit 1

4

20

High-throughput

0.895

High

700885

PSME4
Proteasome activator complex subunit 4

4

13

High-throughput

0.895

High

700861

PSA6
Proteasome subunit alpha type-6

4

20

Small-scale

0.892

High

700495

PSB9
Proteasome subunit beta type-9

3

20

High-throughput

0.861

High

700836

PSB6
Proteasome subunit beta type-6

3

19

High-throughput

0.861

High

700931

PSMA8
Proteasome subunit alpha-type 8

3

20

High-throughput

0.861

High

700934

PSMF1
Proteasome inhibitor PI31 subunit

3

7

High-throughput

0.861

High

700970

PSME2
Proteasome activator complex subunit 2

3

20

High-throughput

0.861

High

127886

PSD11
26S proteasome non-ATPase regulatory subunit 11

3

20

High-throughput

0.847

High

700433

PSB8
Proteasome subunit beta type-8

3

19

Small-scale

0.843

High

700864

PRS8
26S proteasome regulatory subunit 8

3

20

Small-scale

0.827

High

337449

PSMG1
Proteasome assembly chaperone 1

2

6

High-throughput

0.811

High

700843

PSB10
Proteasome subunit beta type-10

2

19

Small-scale

0.793

High

128156

PSD12
26S proteasome non-ATPase regulatory subunit 12

2

20

High-throughput

0.754

High

700892

SMAD1
Mothers against decapentaplegic homolog 1

6

1

Small-scale

0.733

High

700978

FBX7
F-box only protein 7

5

8

Small-scale

0.714

High

700866

PRS10
26S proteasome regulatory subunit 10B

1

20

High-throughput

0.691

High

700984

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

4

20

Small-scale

0.683

High

137975

PSDE
26S proteasome non-ATPase regulatory subunit 14

4

20

Small-scale

0.676

High

700939

PSMG2
Proteasome assembly chaperone 2

3

13

High-throughput

0.667

High

700952

PSMG3
Proteasome assembly chaperone 3

1

7

Small-scale

0.647

High

700877

PSMD2
26S proteasome non-ATPase regulatory subunit 2

3

20

Small-scale

0.641

High

700871

UBE3A
Ubiquitin-protein ligase E3A

3

20

Small-scale

0.640

High

700972

PRP19
Pre-mRNA-processing factor 19

2

6

Small-scale

0.631

High

610235

PRS6A
26S proteasome regulatory subunit 6A

1

20

High-throughput

0.618

High

700842

PRS7
26S proteasome regulatory subunit 7

1

20

High-throughput

0.618

High

700846

PRS6B
26S proteasome regulatory subunit 6B

1

20

High-throughput

0.618

High

700863

PRS4
26S proteasome regulatory subunit 4

1

20

High-throughput

0.618

High

700880

CUL1
Cullin-1

2

8

Small-scale

0.614

High

210866

PSMD3
26S proteasome non-ATPase regulatory subunit 3

2

11

High-throughput

0.611

High

371231

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.611

High

563247

CFTR
Cystic fibrosis transmembrane conductance regulator

2

8

High-throughput

0.611

High

169446

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

4

High-throughput

0.606

High

277081

PROP1
Homeobox protein prophet of Pit-1

2

3

High-throughput

0.606

High

700874

TLE5
TLE family member 5

2

1

High-throughput

0.606

High

700894

PKN1
Serine/threonine-protein kinase N1

2

3

High-throughput

0.606

High

700898

CCD57
Coiled-coil domain-containing protein 57

2

2

High-throughput

0.606

High

700949

PFD5
Prefoldin subunit 5

2

1

High-throughput

0.606

High

700951

PITX2
Pituitary homeobox 2

2

1

High-throughput

0.606

High

700956

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

2

9

High-throughput

0.606

High

700957

SYP2L
Synaptopodin 2-like protein

2

1

High-throughput

0.606

High

240820

PRKN
E3 ubiquitin-protein ligase parkin

2

20

Small-scale

0.601

High

181974

UBD
Ubiquitin D

2

20

Small-scale

0.595

High

700909

Q6IBT1
Proteasome subunit beta

1

19

High-throughput

0.590

High

700847

YAP1
Transcriptional coactivator YAP1

2

14

High-throughput

0.584

High

700858

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

14

High-throughput

0.584

High

700974

PSD13
26S proteasome non-ATPase regulatory subunit 13

2

15

High-throughput

0.584

High

700838

GRAN
Grancalcin

2

0

High-throughput

0.580

High

700845

BCL6
B-cell lymphoma 6 protein

2

0

High-throughput

0.580

High

700899

KR195
Keratin-associated protein 19-5

2

0

High-throughput

0.580

High

700903

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

2

0

High-throughput

0.580

High

700907

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

0

High-throughput

0.580

High

700918

AP2D
Transcription factor AP-2-delta

2

0

High-throughput

0.580

High

700922

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.580

High

700945

TEKT5
Tektin-5

2

0

High-throughput

0.580

High

700960

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.580

High

700963

SPG21
Maspardin

2

0

High-throughput

0.580

High

700964

CNOT2
CCR4-NOT transcription complex subunit 2

2

0

High-throughput

0.580

High

700985

HEMK1
MTRF1L release factor glutamine methyltransferase

2

0

High-throughput

0.580

High

700859

TERA
Transitional endoplasmic reticulum ATPase

1

12

High-throughput

0.575

High

700946

CRBN
Protein cereblon

1

1

Small-scale

0.573

High

51398

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

20

High-throughput

0.573

High

700867

RB11A
Ras-related protein Rab-11A

2

0

High-throughput

0.547

High

603174

KPCA
Protein kinase C alpha type

1

2

High-throughput

0.541

High

700868

SKP1
S-phase kinase-associated protein 1

1

9

High-throughput

0.536

High

700879

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

8

High-throughput

0.536

High

700896

MK06
Mitogen-activated protein kinase 6

1

6

High-throughput

0.536

High

700920

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

20

High-throughput

0.536

High

700926

SLX4
Structure-specific endonuclease subunit SLX4

1

7

High-throughput

0.536

High

700954

FOXP3
Forkhead box protein P3

1

2

High-throughput

0.536

High

700959

NRBP2
Nuclear receptor-binding protein 2

1

3

High-throughput

0.536

High

700969

AMFR
E3 ubiquitin-protein ligase AMFR

1

18

High-throughput

0.536

High

700979

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

8

High-throughput

0.536

High

700986

STK24
Serine/threonine-protein kinase 24

1

8

High-throughput

0.536

High

700870

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.518

High

700942

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

700853

ATX1
Ataxin-1

1

3

High-throughput

0.515

High

700876

TADBP
TAR DNA-binding protein 43

1

2

High-throughput

0.515

High

700977

RNF11
RING finger protein 11

1

20

High-throughput

0.515

High

591489

H2AX
Histone H2AX

1

0

High-throughput

0.513

High

700975

FOXJ3
Forkhead box protein J3

1

0

High-throughput

0.513

High

421546

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

339662

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.500

High

700950

FEV
Protein FEV

1

3

High-throughput

0.500

High

700953

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.500

High

700968

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.500

High

539662

MBL2
Mannose-binding protein C

1

4

High-throughput

0.489

High

700869

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

700884

PDIA5
Protein disulfide-isomerase A5

1

8

High-throughput

0.489

High

700889

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

700890

EPHA7
Ephrin type-A receptor 7

1

3

High-throughput

0.489

High

700923

ST32C
Serine/threonine-protein kinase 32C

1

3

High-throughput

0.489

High

413243

P53
Cellular tumor antigen p53

1

0

High-throughput

0.479

High

186508

TRI18
E3 ubiquitin-protein ligase Midline-1

1

20

Small-scale

0.479

High

259485

BRD4
Bromodomain-containing protein 4

1

9

High-throughput

0.479

High

271920

OBSL1
Obscurin-like protein 1

1

8

High-throughput

0.479

High

293246

CD123
Translation initiation factor eIF2 assembly protein

1

6

High-throughput

0.479

High

302387

RNF8
E3 ubiquitin-protein ligase RNF8

1

8

High-throughput

0.479

High

315155

RECQ4
ATP-dependent DNA helicase Q4

1

10

High-throughput

0.479

High

319429

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

326520

MFN2
Mitofusin-2

1

7

High-throughput

0.479

High

342757

HERC2
E3 ubiquitin-protein ligase HERC2

1

9

High-throughput

0.479

High

347541

BAG3
BAG family molecular chaperone regulator 3

1

7

High-throughput

0.479

High

375203

RASK
GTPase KRas

1

2

High-throughput

0.479

High

379887

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

6

High-throughput

0.479

High

425332

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.479

High

519765

ANDR
Androgen receptor

1

10

High-throughput

0.479

High

520752

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

6

High-throughput

0.479

High

536557

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

587975

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

606274

CEBPB
CCAAT/enhancer-binding protein beta

1

12

High-throughput

0.479

High

607532

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

9

High-throughput

0.479

High

648092

NDKB
Nucleoside diphosphate kinase B

1

6

High-throughput

0.479

High

700839

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.479

High

700840

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

700841

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

4

Small-scale

0.479

High

700844

CCNF
Cyclin-F

1

9

High-throughput

0.479

High

700848

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.479

High

700851

PLK1
Serine/threonine-protein kinase PLK1

1

19

High-throughput

0.479

High

700852

ATX3
Ataxin-3

1

4

High-throughput

0.479

High

700855

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

12

High-throughput

0.479

High

700856

RD23A
UV excision repair protein RAD23 homolog A

1

20

Small-scale

0.479

High

700857

RD23B
UV excision repair protein RAD23 homolog B

1

20

High-throughput

0.479

High

700860

SEM1
26S proteasome complex subunit SEM1

1

5

Small-scale

0.479

High

700862

UBC12
NEDD8-conjugating enzyme Ubc12

1

12

High-throughput

0.479

High

700865

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

12

High-throughput

0.479

High

700872

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

9

High-throughput

0.479

High

700875

DUS4
Dual specificity protein phosphatase 4

1

2

High-throughput

0.479

High

700878

SQSTM
Sequestosome-1

1

5

Small-scale

0.479

High

700882

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

7

High-throughput

0.479

High

700886

CUL7
Cullin-7

1

4

High-throughput

0.479

High

700887

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

20

High-throughput

0.479

High

700888

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

14

High-throughput

0.479

High

700891

UBE3C
Ubiquitin-protein ligase E3C

1

20

High-throughput

0.479

High

700893

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

11

High-throughput

0.479

High

700895

FSCN1
Fascin

1

1

High-throughput

0.479

High

700897

CL16A
Protein CLEC16A

1

3

High-throughput

0.479

High

700900

LARP7
La-related protein 7

1

5

High-throughput

0.479

High

700901

MIDN
Midnolin

1

7

High-throughput

0.479

High

700902

AKIR2
Akirin-2

1

11

Small-scale

0.479

High

700905

DDI2
Protein DDI1 homolog 2

1

20

High-throughput

0.479

High

700906

TET5C
Terminal nucleotidyltransferase 5C

1

4

High-throughput

0.479

High

700908

VIR
Protein virilizer homolog

1

7

High-throughput

0.479

High

700912

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

3

High-throughput

0.479

High

700914

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

700915

MOB3C
MOB kinase activator 3C

1

6

High-throughput

0.479

High

700919

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

12

High-throughput

0.479

High

700921

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.479

High

700924

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

6

Small-scale

0.479

High

700925

GOLI
E3 ubiquitin-protein ligase RNF130

1

20

High-throughput

0.479

High

700928

NHLC2
NHL repeat-containing protein 2

1

5

High-throughput

0.479

High

700930

TNIP2
TNFAIP3-interacting protein 2

1

4

High-throughput

0.479

High

700936

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

20

High-throughput

0.479

High

700937

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

700938

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

Small-scale

0.479

High

700941

OPTN
Optineurin

1

3

High-throughput

0.479

High

700943

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

7

Small-scale

0.479

High

700944

CI072
Guanine nucleotide exchange factor C9orf72

1

7

High-throughput

0.479

High

700948

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.479

High

700955

PIP30
PSME3-interacting protein

1

4

High-throughput

0.479

High

700965

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

700966

UBQL2
Ubiquilin-2

1

20

High-throughput

0.479

High

700971

FZR1
Fizzy-related protein homolog

1

12

High-throughput

0.479

High

700973

UBQL1
Ubiquilin-1

1

20

High-throughput

0.479

High

700980

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

7

Small-scale

0.479

High

700981

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

700982

TRAF6
TNF receptor-associated factor 6

1

9

High-throughput

0.479

High

700854

OAZ1
Ornithine decarboxylase antizyme 1

1

0

Small-scale

0.460

High

128388

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

Small-scale

0.458

High

378475

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.458

High

484941

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

Small-scale

0.458

High

641916

CD9
CD9 antigen

1

0

High-throughput

0.458

High

700910

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

700935

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

700961

MTMRA
Myotubularin-related protein 10

1

0

High-throughput

0.458

High

700967

XPO7
Exportin-7

1

0

High-throughput

0.458

High

700983

NUB1
NEDD8 ultimate buster 1

1

0

Small-scale

0.458

High

465418

IGF1R
Insulin-like growth factor 1 receptor

1

10

High-throughput

0.457

High

429352

JUN
Transcription factor Jun

1

15

High-throughput

0.445

High

529145

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.445

High

700881

DAG1
Dystroglycan 1

1

2

Small-scale

0.445

High

700904

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.445

High

700958

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

353000

AGR2
Anterior gradient protein 2 homolog

1

6

High-throughput

0.437

High

700883

GRM2
Metabotropic glutamate receptor 2

1

7

High-throughput

0.437

High

700911

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

700927

FBXL6
F-box/LRR-repeat protein 6

1

4

High-throughput

0.437

High

700933

DDI1
Protein DDI1 homolog 1

1

20

High-throughput

0.437

High

700962

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

5

High-throughput

0.437

High

700913

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.426

High

700916

NIPA1
Magnesium transporter NIPA1

1

7

High-throughput

0.407

High

700929

MOT11
Monocarboxylate transporter 11

1

7

High-throughput

0.407

High

700917

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

2

0

High-throughput

0.316

High

700932

MYOZ3
Myozenin-3

2

0

High-throughput

0.316

High

700940

CC74A
Coiled-coil domain-containing protein 74A

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025