HitPredict

Interactor 1: SYB (P18489)
Synaptobrevin
Gene: SYB

Interactor 2: Q9VV76 (Q9VV76)
Syntaxin 8
Gene: Syx8

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0005886 - plasma membrane GO:0006906 - vesicle fusion GO:0016081 - synaptic vesicle docking and 1 others more... GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 152 Dm			1 232
+	Dm
		1263473 Q7JYX5_DROME (4-127): 3.99e-39: 133: 14.29		Q9VV76_DROME (1-222): 8.43e-55: 176: 100.00
+	Dm
		121831 M9PGI6_DROME (3-128): 8.27e-37: 127: 16.67		Q9VV76_DROME (1-222): 8.43e-55: 176: 100.00
+	Dm
		305596 O77434_DROME (3-128): 9.32e-37: 127: 16.67		Q9VV76_DROME (1-222): 8.43e-55: 176: 100.00
+	Hs
		249804 SC22B_HUMAN (3-131): 5.15e-39: 132: 18.32		STX10_HUMAN (6-220): 4.68e-51: 168: 15.65
+	Hs
		225883 SC22B_HUMAN (3-131): 5.15e-39: 132: 18.32		STX6_HUMAN (6-220): 2.19e-49: 163: 13.98
+	Hs
		280371 SC22B_HUMAN (3-131): 5.15e-39: 132: 18.32		STX8_HUMAN (7-217): 2.74e-42: 144: 23.50
+	Dm
		614909 SYB_DROME (1-152): 1.12e-53: 168: 100.00		Q7JRF1_DROME (6-144): 2.2e-24: 100: 10.49
+	Dm
		614963 SYB_DROME (1-152): 1.12e-53: 168: 100.00		Q9VVX6_DROME (159-232): 7.92e-21: 86: 13.51
+	Sc
		646264 SEC22_YEAST (3-129): 6.21e-37: 127: 19.38		TLG1_YEAST (6-213): 2.7e-33: 121: 15.39
+	Hs
		179768 SC22B_HUMAN (3-131): 5.15e-39: 132: 18.32		BET1_HUMAN (147-232): 1.11e-25: 98.7: 13.95
+	Sc
		646225 SEC22_YEAST (3-129): 6.21e-37: 127: 19.38		VAM7_YEAST (49-210): 1.35e-25: 103: 17.90
+	At
		866335 VA722_ARATH (3-112): 5.63e-42: 140: 23.89		SNP33_ARATH (14-209): 2.14e-17: 81: 17.09
+	Rn
		1204259 YKT6_RAT (1-101): 9.4e-34: 119: 20.79		BET1_RAT (147-232): 5.87e-27: 101: 15.12
+	At
		1456080 VA721_ARATH (3-112): 1.09e-41: 139: 23.01		SNP33_ARATH (14-209): 2.14e-17: 81: 17.09
+	Dm
		1263475 Q7JYX5_DROME (4-127): 3.99e-39: 133: 14.29		Q9VVX6_DROME (159-232): 7.92e-21: 86: 13.51
+	Mm
		205242 YKT6_MOUSE (1-101): 1.74e-33: 118: 20.79		BET1_MOUSE (147-232): 5.87e-27: 101: 15.12
+	Dm
		121833 M9PGI6_DROME (3-128): 8.27e-37: 127: 16.67		Q9VVX6_DROME (159-232): 7.92e-21: 86: 13.51
+	Dm
		305598 O77434_DROME (3-128): 9.32e-37: 127: 16.67		Q9VVX6_DROME (159-232): 7.92e-21: 86: 13.51
+	Hs
		280356 SC22B_HUMAN (3-131): 5.15e-39: 132: 18.32		BET1L_HUMAN (137-231): 8.07e-12: 61.8: 14.43
+	Rn
		204384 YKT6_RAT (1-101): 9.4e-34: 119: 20.79		BET1L_RAT (143-232): 4.52e-13: 65.2: 17.39