HitPredict

Interactor 1: ATF3 (P18847)
Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)
Gene: ATF3

Interactor 2: ERCC6 (Q03468)
DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)
Gene: ERCC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29225035
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 181 Hs			1 1493
+	Hs
		584013 FOSL1_HUMAN (57-169): 8e-23: 93.4: 35.40		ERCC6_HUMAN (1-1493): 0: 1167: 100.00
+	Hs
		607175 CEBPB_HUMAN (55-148): 2.81e-20: 88: 23.40		CHD7_HUMAN (3-1446): 0: 785: 17.18
+	Hs
		429798 JUN_HUMAN (4-160): 3.3e-22: 93: 18.52		CHD3_HUMAN (317-1445): 0: 747: 19.86
+	Hs
		584090 FOSL2_HUMAN (54-164): 8.4e-22: 91.8: 37.84		CHD3_HUMAN (317-1445): 0: 747: 19.86
+	Hs
		429903 JUN_HUMAN (4-160): 3.3e-22: 93: 18.52		CHD4_HUMAN (317-1426): 0: 725: 19.25
+	Hs
		617137 ATF3_HUMAN (1-181): 2.88e-40: 136: 100.00		SMCA4_HUMAN (228-1299): 0: 681: 20.36
+	Hs
		606773 CEBPB_HUMAN (55-148): 2.81e-20: 88: 23.40		CHD4_HUMAN (317-1426): 0: 725: 19.25
+	Mm
		1059008 NFE2_MOUSE (10-179): 1.33e-21: 91.8: 18.39		CHD4_MOUSE (317-1426): 0: 711: 18.91
+	Hs
		429550 JUN_HUMAN (4-160): 3.3e-22: 93: 18.52		SMCA2_HUMAN (228-1388): 0: 684: 18.32
+	Hs
		370603 FOS_HUMAN (14-175): 3.48e-21: 90.6: 20.34		SMCA2_HUMAN (228-1388): 0: 684: 18.32
+	Hs
		429551 JUN_HUMAN (4-160): 3.3e-22: 93: 18.52		SMCA4_HUMAN (228-1299): 0: 681: 20.36
+	Hs
		606453 CEBPB_HUMAN (55-148): 2.81e-20: 88: 23.40		SMCA2_HUMAN (228-1388): 0: 684: 18.32
+	Hs
		370604 FOS_HUMAN (14-175): 3.48e-21: 90.6: 20.34		SMCA4_HUMAN (228-1299): 0: 681: 20.36
+	Hs
		603629 JUNB_HUMAN (31-156): 4.24e-21: 90.3: 19.85		SMCA4_HUMAN (228-1299): 0: 681: 20.36
+	Hs
		606454 CEBPB_HUMAN (55-148): 2.81e-20: 88: 23.40		SMCA4_HUMAN (228-1299): 0: 681: 20.36
+	Mm
		432092 JUN_MOUSE (4-160): 1.5e-21: 91: 19.39		SMCA2_MOUSE (88-1363): 0: 677: 17.33
+	Mm
		370855 FOS_MOUSE (13-175): 2.06e-20: 88.7: 25.43		SMCA2_MOUSE (88-1363): 0: 677: 17.33
+	Hs
		243532 CEBPB_HUMAN (55-148): 2.81e-20: 88: 23.40		SMCA5_HUMAN (381-1322): 0: 670: 23.45
+	Hs
		429357 JUN_HUMAN (4-160): 3.3e-22: 93: 18.52		SMCA1_HUMAN (370-1322): 0: 665: 22.14
+	Hs
		173643 JUN_HUMAN (4-160): 3.3e-22: 93: 18.52		BTAF1_HUMAN (490-1019): 9.63e-80: 293: 35.50