HitPredict

Interactor 1: GNAZ (P19086)
Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha)
Gene: GNAZ

Interactor 2: GBG2 (P59768)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)
Gene: GNG2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0045202 - synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 355 Hs			1 71
+	Hs
		418632 GNAI2_HUMAN (1-354): 5.01e-177: 496: 66.38		GBG2_HUMAN (1-71): 3.59e-29: 100: 100.00
+	Hs
		948054 GNAI1_HUMAN (1-354): 1.84e-176: 495: 67.23		GBG2_HUMAN (1-71): 3.59e-29: 100: 100.00
+	Hs
		418625 GNAI2_HUMAN (1-354): 5.01e-177: 496: 66.38		GBG4_HUMAN (1-71): 6.57e-28: 97: 77.47
+	Hs
		893553 GNAI1_HUMAN (1-354): 1.84e-176: 495: 67.23		GBG4_HUMAN (1-71): 6.57e-28: 97: 77.47
+	Hs
		418646 GNAI2_HUMAN (1-354): 5.01e-177: 496: 66.38		GBG3_HUMAN (4-71): 3.15e-27: 95.1: 79.41
+	Hs
		482595 GNAO_HUMAN (1-354): 5.83e-175: 491: 60.45		GBG2_HUMAN (1-71): 3.59e-29: 100: 100.00
+	Hs
		989826 GNAI1_HUMAN (1-354): 1.84e-176: 495: 67.23		GBG3_HUMAN (4-71): 3.15e-27: 95.1: 79.41
+	Hs
		418762 GNAI2_HUMAN (1-354): 5.01e-177: 496: 66.38		GBG8_HUMAN (3-71): 8.54e-26: 91.7: 71.01
+	Hs
		989890 GNAI1_HUMAN (1-354): 1.84e-176: 495: 67.23		GBG8_HUMAN (3-71): 8.54e-26: 91.7: 71.01
+	Hs
		482602 GNAO_HUMAN (1-354): 5.83e-175: 491: 60.45		GBG3_HUMAN (4-71): 3.15e-27: 95.1: 79.41
+	Hs
		243462 GNAI2_HUMAN (1-354): 5.01e-177: 496: 66.38		GBG7_HUMAN (4-71): 4.44e-25: 89.7: 70.59
+	Hs
		243468 GNAI1_HUMAN (1-354): 1.84e-176: 495: 67.23		GBG7_HUMAN (4-71): 4.44e-25: 89.7: 70.59
+	Hs
		418759 GNAI2_HUMAN (1-354): 5.01e-177: 496: 66.38		GBG12_HUMAN (3-71): 4.48e-24: 87: 62.32
+	Hs
		989887 GNAI1_HUMAN (1-354): 1.84e-176: 495: 67.23		GBG12_HUMAN (3-71): 4.48e-24: 87: 62.32
+	Hs
		418626 GNAI2_HUMAN (1-354): 5.01e-177: 496: 66.38		GBG10_HUMAN (4-71): 4.36e-22: 82: 52.94
+	Hs
		482646 GNAO_HUMAN (1-354): 5.83e-175: 491: 60.45		GBG12_HUMAN (3-71): 4.48e-24: 87: 62.32
+	Hs
		893567 GNAI1_HUMAN (1-354): 1.84e-176: 495: 67.23		GBG10_HUMAN (4-71): 4.36e-22: 82: 52.94
+	Hs
		418647 GNAI2_HUMAN (1-354): 5.01e-177: 496: 66.38		GBG5_HUMAN (4-71): 4.13e-21: 79.7: 48.53
+	Hs
		989827 GNAI1_HUMAN (1-354): 1.84e-176: 495: 67.23		GBG5_HUMAN (4-71): 4.13e-21: 79.7: 48.53
+	Hs
		482590 GNAO_HUMAN (1-354): 5.83e-175: 491: 60.45		GBG10_HUMAN (4-71): 4.36e-22: 82: 52.94