HitPredict

Interactor 1: CCND1 (P24385)
G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)
Gene: CCND1

Interactor 2: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17274640
Identification Methods	affinity chromatography technology, antibody array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding and 1 others more... GO:0051301 - cell division
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 295 Hs			1 327
+	Hs
		538509 CCNB1_HUMAN (5-282): 3.94e-89: 273: 20.64		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Mm
		624388 CCNB1_MOUSE (5-286): 9.4e-87: 267: 20.50		PP1B_MOUSE (1-327): 0: 597: 100.00
+	Mm
		673183 CCND3_MOUSE (4-295): 5.1e-86: 261: 50.51		PP1B_MOUSE (1-327): 0: 597: 100.00
+	Hs
		905830 CCNA1_HUMAN (7-281): 7.64e-89: 274: 23.91		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		538508 CCNB1_HUMAN (5-282): 3.94e-89: 273: 20.64		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Mm
		624387 CCNB1_MOUSE (5-286): 9.4e-87: 267: 20.50		PP1A_MOUSE (1-326): 0: 576: 88.49
+	Hs
		538485 CCNB1_HUMAN (5-282): 3.94e-89: 273: 20.64		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Mm
		906272 CCNA1_MOUSE (15-281): 6.39e-86: 265: 24.63		PP1A_MOUSE (1-326): 0: 576: 88.49
+	Mm
		673182 CCND3_MOUSE (4-295): 5.1e-86: 261: 50.51		PP1A_MOUSE (1-326): 0: 576: 88.49
+	Mm
		624389 CCNB1_MOUSE (5-286): 9.4e-87: 267: 20.50		PP1G_MOUSE (1-327): 0: 569: 86.89
+	Hs
		673136 CCND3_HUMAN (3-295): 2.73e-76: 236: 51.69		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Mm
		673184 CCND3_MOUSE (4-295): 5.1e-86: 261: 50.51		PP1G_MOUSE (1-327): 0: 569: 86.89
+	Mm
		629209 CCND1_MOUSE (1-295): 1.76e-82: 252: 93.90		PP1G_MOUSE (1-327): 0: 569: 86.89
+	Hs
		673135 CCND3_HUMAN (3-295): 2.73e-76: 236: 51.69		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		673126 CCND3_HUMAN (3-295): 2.73e-76: 236: 51.69		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		622375 CCND1_HUMAN (1-295): 1.33e-74: 232: 100.00		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		915161 CCNA1_HUMAN (7-281): 7.64e-89: 274: 23.91		PP2AB_HUMAN (8-303): 1.26e-176: 492: 46.13
+	Hs
		673059 CCND2_HUMAN (3-295): 5.15e-81: 248: 61.22		PP2AA_HUMAN (8-303): 2.77e-176: 491: 45.79