HitPredict

Interactor 1: S1PR1 (P21453)
Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363)
Gene: S1PR1

Interactor 2: S39A6 (Q13433)
Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6)
Gene: SLC39A6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045121 - membrane raft
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 382 Hs			1 755
+	Hs
		1105227 LPAR1_HUMAN (23-342): 6.25e-89: 274: 38.51		S39A6_HUMAN (1-755): 0: 620: 100.00
+	Hs
		351893 S1PR4_HUMAN (1-329): 2.25e-81: 255: 39.76		S39A6_HUMAN (1-755): 0: 620: 100.00
+	Hs
		1105245 LPAR2_HUMAN (23-365): 5.57e-76: 240: 34.88		S39A6_HUMAN (1-755): 0: 620: 100.00
+	Hs
		221452 OX2R_HUMAN (1-375): 2.61e-68: 223: 17.13		S39A6_HUMAN (1-755): 0: 620: 100.00
+	Hs
		1366301 LPAR1_HUMAN (23-342): 6.25e-89: 274: 38.51		S39AA_HUMAN (1-755): 4.26e-162: 491: 33.69
+	Hs
		351985 S1PR4_HUMAN (1-329): 2.25e-81: 255: 39.76		S39AA_HUMAN (1-755): 4.26e-162: 491: 33.69
+	Hs
		638260 S1PR1_HUMAN (1-382): 1.52e-79: 250: 100.00		S39AA_HUMAN (1-755): 4.26e-162: 491: 33.69
+	Hs
		1438467 LPAR2_HUMAN (23-365): 5.57e-76: 240: 34.88		S39AA_HUMAN (1-755): 4.26e-162: 491: 33.69
+	Hs
		1139524 LPAR1_HUMAN (23-342): 6.25e-89: 274: 38.51		S39AE_HUMAN (215-749): 1.13e-106: 336: 27.59
+	Hs
		458403 ADRB2_HUMAN (50-372): 4e-69: 224: 19.60		S39AE_HUMAN (215-749): 1.13e-106: 336: 27.59
+	Hs
		762128 CNR2_HUMAN (47-367): 1.48e-66: 216: 25.23		S39AE_HUMAN (215-749): 1.13e-106: 336: 27.59
+	Hs
		1366275 LPAR1_HUMAN (23-342): 6.25e-89: 274: 38.51		S39A1_HUMAN (559-742): 3.83e-37: 143: 16.49
+	Hs
		351913 S1PR4_HUMAN (1-329): 2.25e-81: 255: 39.76		S39A4_HUMAN (229-390): 1.77e-32: 135: 20.73
+	Hs
		638202 S1PR1_HUMAN (1-382): 1.52e-79: 250: 100.00		S39A4_HUMAN (229-390): 1.77e-32: 135: 20.73
+	Hs
		1242939 LPAR2_HUMAN (23-365): 5.57e-76: 240: 34.88		S39A4_HUMAN (229-390): 1.77e-32: 135: 20.73
+	Hs
		1242932 S1PR5_HUMAN (22-376): 1.86e-71: 230: 46.11		S39A4_HUMAN (229-390): 1.77e-32: 135: 20.73
+	Hs
		762165 CNR2_HUMAN (47-367): 1.48e-66: 216: 25.23		S39A2_HUMAN (555-746): 6.73e-38: 145: 18.78
+	Hs
		1116397 5HT4R_HUMAN (42-382): 2.26e-66: 217: 22.04		S39A1_HUMAN (559-742): 3.83e-37: 143: 16.49
+	Hs
		458432 ADRB2_HUMAN (50-372): 4e-69: 224: 19.60		S39A4_HUMAN (229-390): 1.77e-32: 135: 20.73
+	Hs
		770901 OPRM_HUMAN (3-360): 2.37e-67: 219: 15.80		S39AD_HUMAN (292-456): 1.75e-25: 111: 17.06