HitPredict

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 375
+	Hs
		965115 ANK2_HUMAN (118-315): 9.61e-41: 153: 23.50		ACTBL_HUMAN (2-375): 0: 734: 91.44
+	Hs
		587598 NFKB1_HUMAN (31-196): 3.47e-20: 93.1: 23.35		ACTBL_HUMAN (2-375): 0: 734: 91.44
+	Hs
		929823 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		ACTG_HUMAN (1-375): 0: 604: 100.00
+	Hs
		862022 DAPK1_HUMAN (27-317): 1.12e-62: 216: 17.11		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Hs
		891699 ANK2_HUMAN (118-315): 9.61e-41: 153: 23.50		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		930079 ANK2_HUMAN (118-315): 9.61e-41: 153: 23.50		ACTH_HUMAN (2-375): 0: 592: 94.39
+	Rn
		251023 ANK3_RAT (1-130): 1.77e-30: 123: 10.77		ACTB_RAT (1-375): 0: 604: 98.93
+	Hs
		587489 NFKB1_HUMAN (31-196): 3.47e-20: 93.1: 23.35		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		891882 ANKH1_HUMAN (4-107): 2.55e-18: 87.9: 6.73		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		587503 NFKB1_HUMAN (31-196): 3.47e-20: 93.1: 23.35		ACTA_HUMAN (2-375): 0: 594: 94.39
+	Hs
		929874 IKBB_HUMAN (68-169): 5.17e-13: 70.8: 28.16		ACTG_HUMAN (1-375): 0: 604: 100.00