HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.50	0.512

Property	Details
Experiments	22261253
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 156
+	Hs
		641701 ERBB3_HUMAN (1-1342): 0: 1390: 100.00		KDIS_HUMAN (86-156): 3.21e-12: 65: 19.48
+	Hs
		62906 ERBB3_HUMAN (1-1342): 0: 1390: 100.00		POTEF_HUMAN (82-149): 1.91e-10: 60: 21.13
+	Hs
		641616 ERBB3_HUMAN (1-1342): 0: 1390: 100.00		POTEE_HUMAN (82-149): 2.13e-10: 59.6: 21.13
+	Hs
		410693 ERBB2_HUMAN (25-1222): 0: 1075: 39.95		CDN2B_HUMAN (3-136): 4.73e-52: 163: 81.34
+	Hs
		363206 EGFR_HUMAN (18-1211): 0: 1060: 40.65		ANK3_HUMAN (3-153): 3.24e-36: 133: 16.94
+	Hs
		410694 ERBB2_HUMAN (25-1222): 0: 1075: 39.95		CDN2C_HUMAN (21-135): 9.52e-26: 97.8: 28.21
+	Hs
		363144 EGFR_HUMAN (18-1211): 0: 1060: 40.65		ANK2_HUMAN (3-63): 3.65e-14: 70.7: 24.19
+	Hs
		364015 EGFR_HUMAN (18-1211): 0: 1060: 40.65		KDIS_HUMAN (86-156): 3.21e-12: 65: 19.48
+	Hs
		363949 EGFR_HUMAN (18-1211): 0: 1060: 40.65		RAI14_HUMAN (1-64): 1e-11: 63.4: 21.21
+	Hs
		842731 ROR1_HUMAN (490-1147): 1.52e-125: 414: 17.37		CDN2A_HUMAN (1-156): 9.11e-52: 163: 100.00
+	Hs
		463950 RET_HUMAN (518-1072): 5.32e-118: 397: 21.15		ANK3_HUMAN (3-153): 3.24e-36: 133: 16.94
+	Hs
		710109 EPHA2_HUMAN (665-996): 2e-104: 357: 29.40		CDN2A_HUMAN (1-156): 9.11e-52: 163: 100.00
+	Hs
		710110 EPHA2_HUMAN (665-996): 2e-104: 357: 29.40		CDN2B_HUMAN (3-136): 4.73e-52: 163: 81.34
+	Hs
		362221 ABL1_HUMAN (696-1307): 2.1e-132: 438: 22.51		DAPK1_HUMAN (69-155): 1.65e-14: 71.5: 24.14
+	Hs
		710822 EPHB2_HUMAN (635-993): 3.15e-106: 364: 28.00		ANK3_HUMAN (3-153): 3.24e-36: 133: 16.94
+	Hs
		710207 EPHA2_HUMAN (665-996): 2e-104: 357: 29.40		ANK3_HUMAN (3-153): 3.24e-36: 133: 16.94
+	Hs
		1034335 ROR2_HUMAN (491-1088): 8.52e-118: 393: 20.22		TANC1_HUMAN (56-154): 1.19e-14: 71.9: 21.00
+	Hs
		710111 EPHA2_HUMAN (665-996): 2e-104: 357: 29.40		CDN2C_HUMAN (21-135): 9.52e-26: 97.8: 28.21
+	Hs
		710812 EPHB2_HUMAN (635-993): 3.15e-106: 364: 28.00		ANK2_HUMAN (3-63): 3.65e-14: 70.7: 24.19
+	Hs
		710530 EPHA2_HUMAN (665-996): 2e-104: 357: 29.40		RAI14_HUMAN (1-64): 1e-11: 63.4: 21.21