HitPredict

Interactor 1: U2AF2 (P26368)
Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)
Gene: U2AF2

Interactor 2: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 475 Hs			1 499
+	Hs
		641667 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		625442 SART3_HUMAN (10-377): 4.33e-86: 285: 22.52		CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70
+	Hs
		833874 ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42		CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00
+	Hs
		834030 ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		625400 ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42		CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70
+	Hs
		833880 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00
+	Hs
		833736 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31
+	Dm
		834204 Q9VM49_DROME (16-470): 2.22e-72: 241: 18.36		DOA_DROME (8-494): 4.91e-114: 357: 51.83
+	Hs
		834041 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		414931 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		CDK1_HUMAN (160-485): 3.05e-114: 340: 23.95
+	Hs
		1043817 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		1020254 ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		1043793 ELAV3_HUMAN (127-472): 9.26e-67: 220: 13.98		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		834140 PUF60_HUMAN (92-474): 7.84e-23: 103: 21.50		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		1043792 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		834033 PABP4_HUMAN (41-251): 2.07e-19: 93: 12.78		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		625633 PUF60_HUMAN (92-474): 7.84e-23: 103: 21.50		CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70
+	Hs
		516362 PABP1_HUMAN (41-247): 3.26e-19: 92.6: 14.35		CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70
+	Hs
		642764 ELAV4_HUMAN (88-342): 7.66e-39: 146: 13.33		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		1031320 PABP4_HUMAN (41-251): 2.07e-19: 93: 12.78		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50