HitPredict

Interactor 1: PTBP1 (P26599)
Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)
Gene: PTBP1

Interactor 2: PTBP2 (Q9UKA9)
Polypyrimidine tract-binding protein 2 (Neural polypyrimidine tract-binding protein) (Neurally-enriched homolog of PTB) (PTB-like protein)
Gene: PTBP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.870

The method score is based on:

Property Details
Experiments 34133714, 34349018, 35235311, 31515488
Identification Methods two hybrid, cross-linking study, two hybrid array
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains RRM_1~RRM_1, RRM_1~RRM_5, RRM_5~RRM_5, RRM_8~RRM_8
Common GO terms GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0033119 - negative regulation of RNA splicing
GO:0043484 - regulation of RNA splicing
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 557
Hs

1 531
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024