HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: BCAR1 (P56945)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene: BCAR1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 870
+	Hs
		710621 EPHA3_HUMAN (1-786): 0: 641: 20.68		DYST_HUMAN (457-866): 1.24e-66: 245: 12.07
+	Hs
		710574 EPHA2_HUMAN (6-788): 0: 593: 21.70		MACF1_HUMAN (505-867): 2.95e-74: 268: 13.79
+	Hs
		710187 EPHA2_HUMAN (6-788): 0: 593: 21.70		DYST_HUMAN (457-866): 1.24e-66: 245: 12.07
+	Hs
		710840 EPHB2_HUMAN (6-788): 0: 629: 19.23		ITSN1_HUMAN (2-173): 5.21e-24: 111: 23.16
+	Hs
		1040305 NTRK2_HUMAN (159-756): 9.3e-162: 491: 25.51		DYST_HUMAN (457-866): 1.24e-66: 245: 12.07
+	Hs
		710876 EPHB2_HUMAN (6-788): 0: 629: 19.23		SH3K1_HUMAN (7-294): 1.08e-16: 86.7: 16.44
+	Hs
		411771 NTRK1_HUMAN (158-756): 6.61e-146: 449: 27.02		DYST_HUMAN (457-866): 1.24e-66: 245: 12.07
+	Hs
		1060780 NTRK3_HUMAN (130-757): 2.26e-167: 506: 24.59		ACK1_HUMAN (9-499): 5.89e-30: 130: 15.35
+	Hs
		1060782 NTRK2_HUMAN (159-756): 9.3e-162: 491: 25.51		ACK1_HUMAN (9-499): 5.89e-30: 130: 15.35
+	Hs
		532098 KIT_HUMAN (19-794): 5.82e-166: 507: 24.62		SH3K1_HUMAN (7-294): 1.08e-16: 86.7: 16.44
+	Hs
		411803 NTRK1_HUMAN (158-756): 6.61e-146: 449: 27.02		ACK1_HUMAN (9-499): 5.89e-30: 130: 15.35
+	Hs
		274075 NTRK1_HUMAN (158-756): 6.61e-146: 449: 27.02		ANR17_HUMAN (69-494): 5.56e-27: 121: 14.82
+	Hs
		412342 NTRK1_HUMAN (158-756): 6.61e-146: 449: 27.02		TITIN_HUMAN (56-404): 7.29e-09: 62.1: 14.93
+	Hs
		541417 FGFR1_HUMAN (1-114): 5.62e-13: 74.7: 18.32		BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00
+	Dm
		1469746 CAD96_DROME (464-752): 8.07e-82: 280: 44.98		Q9VLS7_DROME (113-735): 7.36e-11: 68.4: 9.35
+	Hs
		541448 FGFR1_HUMAN (1-114): 5.62e-13: 74.7: 18.32		ACK1_HUMAN (9-499): 5.89e-30: 130: 15.35
+	Hs
		778068 VGFR2_HUMAN (5-342): 3.96e-17: 88.6: 16.32		MDC1_HUMAN (56-759): 1.44e-20: 100: 8.77
+	Hs
		541509 FGFR1_HUMAN (1-114): 5.62e-13: 74.7: 18.32		ITSN1_HUMAN (2-173): 5.21e-24: 111: 23.16
+	Hs
		777742 VGFR3_HUMAN (7-245): 8.87e-15: 81: 18.22		SH3K1_HUMAN (7-294): 1.08e-16: 86.7: 16.44
+	Hs
		215899 FGFR1_HUMAN (1-114): 5.62e-13: 74.7: 18.32		SYNJ1_HUMAN (283-711): 9.78e-09: 61.4: 12.88