HitPredict

Interactor 1: P121C (A8CG34)
Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C)
Gene: POM121C

Interactor 2: IMB1 (Q14974)
Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97)
Gene: KPNB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	26496610, 35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005635 - nuclear envelope GO:0005643 - nuclear pore GO:0005654 - nucleoplasm GO:0006606 - protein import into nucleus GO:0008139 - nuclear localization sequence binding and 1 others more... GO:0031965 - nuclear membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1229 Hs			1 876
+	Hs
		1060869 P121A_HUMAN (1-1229): 8.01e-79: 286: 93.69		IMB1_HUMAN (1-876): 0: 635: 100.00
+	Hs
		1056831 MDC1_HUMAN (80-893): 2.1e-29: 129: 10.92		IMB1_HUMAN (1-876): 0: 635: 100.00
+	Hs
		72728 B4DET5_HUMAN (5-742): 3.52e-12: 72.9: 9.72		IMB1_HUMAN (1-876): 0: 635: 100.00
+	Hs
		727254 NU214_HUMAN (91-936): 1.02e-10: 68.8: 10.61		IMB1_HUMAN (1-876): 0: 635: 100.00
+	Xl
		853819 Q5EWX9_XENLA (279-1229): 4.98e-12: 72.7: 13.89		IMB_XENLA (1-876): 0: 631: 94.52
+	Hs
		857978 NUP98_HUMAN (784-1215): 1.89e-09: 64.3: 20.76		IMB1_HUMAN (1-876): 0: 635: 100.00
+	Sc
		774378 NU159_YEAST (793-1199): 1.64e-10: 67.8: 21.05		IMB1_YEAST (2-871): 8.02e-148: 459: 33.33
+	Dm
		1370249 Q9VLS7_DROME (3-859): 2e-15: 84.1: 9.65		Q9VPR5_DROME (134-849): 6.61e-81: 287: 12.04
+	Hs
		268793 ARI1B_HUMAN (129-1213): 3.55e-15: 83.3: 9.44		SF3B1_HUMAN (146-866): 1.96e-78: 279: 12.23
+	Hs
		127345 P121A_HUMAN (1-1229): 8.01e-79: 286: 93.69		IPO5_HUMAN (89-863): 6.82e-13: 75: 10.97
+	Hs
		268905 SRRM2_HUMAN (217-944): 3.59e-09: 63.6: 10.44		SF3B1_HUMAN (146-866): 1.96e-78: 279: 12.23
+	Sc
		687954 NU159_YEAST (793-1199): 1.64e-10: 67.8: 21.05		IMB3_YEAST (3-831): 2.12e-34: 144: 16.29
+	Hs
		727300 NU214_HUMAN (91-936): 1.02e-10: 68.8: 10.61		TNPO1_HUMAN (125-870): 3.59e-28: 123: 12.21
+	Hs
		858024 NUP98_HUMAN (784-1215): 1.89e-09: 64.3: 20.76		TNPO1_HUMAN (125-870): 3.59e-28: 123: 12.21
+	Hs
		155553 NUP98_HUMAN (784-1215): 1.89e-09: 64.3: 20.76		TNPO2_HUMAN (124-869): 4.11e-25: 114: 14.04
+	Hs
		127176 MUC1_HUMAN (47-509): 1.16e-20: 100: 11.64		IPO5_HUMAN (89-863): 6.82e-13: 75: 10.97
+	Hs
		127197 NU214_HUMAN (91-936): 1.02e-10: 68.8: 10.61		IPO5_HUMAN (89-863): 6.82e-13: 75: 10.97