Protein: IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)]

Gene: IL16
Organism: Homo sapiens
Interactions: 135
UniProt ID: Q14005

Gene Ontology (top 5):
GO:0005125 - cytokine activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1119727

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

17

Small-scale

0.807

High

466029

ANXA6
Annexin A6

2

2

High-throughput

0.783

High

1119788

PDLI7
PDZ and LIM domain protein 7

2

15

High-throughput

0.783

High

1119789

PICK1
PRKCA-binding protein

2

5

High-throughput

0.783

High

1119752

TRI42
Tripartite motif-containing protein 42

2

20

High-throughput

0.700

High

1119762

LNX1
E3 ubiquitin-protein ligase LNX

2

18

High-throughput

0.700

High

1119771

LMBL3
Lethal(3)malignant brain tumor-like protein 3

2

3

High-throughput

0.700

High

1119797

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

20

High-throughput

0.700

High

1119728

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

4

15

High-throughput

0.692

High

167601

GIPC1
PDZ domain-containing protein GIPC1

1

2

High-throughput

0.665

High

1119734

Q17RH5
Rap guanine nucleotide exchange factor 2

1

10

High-throughput

0.665

High

351534

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

3

9

High-throughput

0.661

High

1119795

TFP11
Tuftelin-interacting protein 11

3

2

High-throughput

0.661

High

1119747

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

3

15

High-throughput

0.660

High

1055652

GABP1
GA-binding protein subunit beta-1

4

20

Small-scale

0.631

High

1119755

LNX2
Ligand of Numb protein X 2

1

18

High-throughput

0.621

High

1119803

RPGF2
Rap guanine nucleotide exchange factor 2

1

10

High-throughput

0.621

High

1059632

KRA11
Keratin-associated protein 1-1

2

16

High-throughput

0.615

High

1119758

RN169
E3 ubiquitin-protein ligase RNF169

2

10

High-throughput

0.611

High

217088

MS18B
Protein Mis18-beta

2

1

High-throughput

0.606

High

220769

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

2

2

High-throughput

0.606

High

227219

KRT86
Keratin, type II cuticular Hb6

2

8

High-throughput

0.606

High

269199

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

571967

TRI27
Zinc finger protein RFP

2

9

High-throughput

0.606

High

783266

TRI23
E3 ubiquitin-protein ligase TRIM23

2

11

High-throughput

0.606

High

950473

KR108
Keratin-associated protein 10-8

2

16

High-throughput

0.606

High

1095622

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

2

18

High-throughput

0.606

High

1119729

FHL2
Four and a half LIM domains protein 2

2

13

High-throughput

0.606

High

1119731

K1H1
Keratin, type I cuticular Ha1

2

15

High-throughput

0.606

High

1119733

DUS7
Dual specificity protein phosphatase 7

2

8

High-throughput

0.606

High

1119751

KRA13
Keratin-associated protein 1-3

2

16

High-throughput

0.606

High

1119768

HOOK2
Protein Hook homolog 2

2

17

High-throughput

0.606

High

1119769

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

1

High-throughput

0.606

High

1119770

PP16A
Protein phosphatase 1 regulatory subunit 16A

2

14

High-throughput

0.606

High

1119772

KI16B
Kinesin-like protein KIF16B

2

20

High-throughput

0.606

High

1119776

TRIB3
Tribbles homolog 3

2

11

High-throughput

0.606

High

1119777

PFD5
Prefoldin subunit 5

2

1

High-throughput

0.606

High

1119780

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

2

6

High-throughput

0.606

High

1119784

WWTR1
WW domain-containing transcription regulator protein 1

2

20

High-throughput

0.606

High

1119791

PRR13
Proline-rich protein 13

2

1

High-throughput

0.606

High

1119794

CEP72
Centrosomal protein of 72 kDa

2

3

High-throughput

0.606

High

1119796

ZRAN1
Ubiquitin thioesterase ZRANB1

2

12

High-throughput

0.606

High

1119757

USBP1
Harmonin-binding protein USHBP1

3

6

High-throughput

0.604

High

239313

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

19

Small-scale

0.594

High

1119738

UBX11
UBX domain-containing protein 11

2

0

High-throughput

0.580

High

1119748

NOXA1
NADPH oxidase activator 1

2

0

High-throughput

0.580

High

1119775

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.580

High

1119781

KRA31
Keratin-associated protein 3-1

2

0

High-throughput

0.580

High

1119783

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

2

0

High-throughput

0.580

High

188274

HDAC3
Histone deacetylase 3

1

4

Small-scale

0.578

High

171243

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

15

Small-scale

0.573

High

378862

CD4
T-cell surface glycoprotein CD4

1

1

Small-scale

0.561

High

537135

HSP7C
Heat shock cognate 71 kDa protein

1

11

Small-scale

0.561

High

1119800

ZN148
Zinc finger protein 148

2

4

High-throughput

0.558

High

65042

GG6L9
Golgin subfamily A member 6-like protein 9

2

18

High-throughput

0.553

High

70201

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.553

High

581768

MYOG
Myogenin

2

1

High-throughput

0.553

High

892399

ZN165
Zinc finger protein 165

2

3

High-throughput

0.553

High

913878

ZN143
Zinc finger protein 143

2

1

High-throughput

0.553

High

1063238

GOGA2
Golgin subfamily A member 2

2

16

High-throughput

0.553

High

1086582

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

2

1

High-throughput

0.553

High

1119736

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

19

High-throughput

0.553

High

1119739

FHL5
Four and a half LIM domains protein 5

2

13

High-throughput

0.553

High

1119740

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

20

High-throughput

0.553

High

1119741

ZN774
Zinc finger protein 774

2

1

High-throughput

0.553

High

1119744

KCTD9
BTB/POZ domain-containing protein KCTD9

2

20

High-throughput

0.553

High

1119750

F124A
Protein FAM124A

2

3

High-throughput

0.553

High

1119754

MIER2
Mesoderm induction early response protein 2

2

1

High-throughput

0.553

High

1119761

LMO3
LIM domain only protein 3

2

8

High-throughput

0.553

High

1119763

PPL13
Placental protein 13-like

2

3

High-throughput

0.553

High

1119774

JKIP1
Janus kinase and microtubule-interacting protein 1

2

11

High-throughput

0.553

High

1119778

KIFC3
Kinesin-like protein KIFC3

2

18

High-throughput

0.553

High

1119779

CAR10
Caspase recruitment domain-containing protein 10

2

19

High-throughput

0.553

High

1119785

GO45
Golgin-45

2

1

High-throughput

0.553

High

1119787

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

4

High-throughput

0.553

High

1119792

ZIM2
Zinc finger imprinted 2

2

2

High-throughput

0.553

High

1119793

ZN581
Zinc finger protein 581

2

5

High-throughput

0.553

High

1119799

ZN777
Zinc finger protein 777

2

1

High-throughput

0.553

High

443357

CDK1
Cyclin-dependent kinase 1

1

7

Small-scale

0.550

High

997705

CSK21
Casein kinase II subunit alpha

1

5

Small-scale

0.550

High

1119773

DMRTB
Doublesex- and mab-3-related transcription factor B1

2

1

High-throughput

0.543

High

1119782

PP12C
Protein phosphatase 1 regulatory subunit 12C

1

17

Small-scale

0.523

High

167264

KLF11
Krueppel-like factor 11

1

4

High-throughput

0.515

High

361695

F13A
Coagulation factor XIII A chain

1

1

High-throughput

0.515

High

384410

CRYAA
Alpha-crystallin A chain

1

2

High-throughput

0.515

High

385730

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

17

High-throughput

0.515

High

415556

HSPB1
Heat shock protein beta-1

1

2

High-throughput

0.515

High

451155

NFL
Neurofilament light polypeptide

1

18

High-throughput

0.515

High

570421

GFAP
Glial fibrillary acidic protein

1

18

High-throughput

0.515

High

843552

HD
Huntingtin

1

5

High-throughput

0.515

High

856681

BAG6
Large proline-rich protein BAG6

1

4

High-throughput

0.515

High

954466

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

1

High-throughput

0.515

High

1119730

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.515

High

1119766

KLK6
Kallikrein-6

1

3

High-throughput

0.515

High

1119767

COQA1
Collagen alpha-1(XXVI) chain

1

1

High-throughput

0.515

High

216435

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

4

High-throughput

0.508

High

1119732

TRIP6
Thyroid receptor-interacting protein 6

1

12

High-throughput

0.508

High

641950

CD9
CD9 antigen

1

2

Small-scale

0.494

High

705331

GRN
Progranulin

1

0

High-throughput

0.493

High

1119746

R144B
E3 ubiquitin-protein ligase RNF144B

1

2

High-throughput

0.481

High

1119753

HOMEZ
Homeobox and leucine zipper protein Homez

1

2

High-throughput

0.481

High

488473

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

3

Small-scale

0.479

High

553352

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

6

Small-scale

0.479

High

1101811

SKP2
S-phase kinase-associated protein 2

1

3

Small-scale

0.479

High

1119759

FXL13
F-box and leucine-rich repeat protein 13

1

1

Small-scale

0.479

High

1119760

NPB
Neuropeptide B

1

1

High-throughput

0.479

High

109400

G5E9A7
DM1 locus, WD repeat containing

1

8

High-throughput

0.470

High

245934

KIF1B
Kinesin-like protein KIF1B

1

20

High-throughput

0.470

High

301419

WFS1
Wolframin

1

1

High-throughput

0.470

High

1119749

Q86V38
Atrophin 1

1

7

High-throughput

0.470

High

1119802

RNF11
RING finger protein 11

1

3

High-throughput

0.470

High

239059

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.464

High

246592

KDM1A
Lysine-specific histone demethylase 1A

1

2

High-throughput

0.464

High

1119786

BOLA2
BolA-like protein 2

1

0

High-throughput

0.460

High

1032954

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

1119756

CCD33
Coiled-coil domain-containing protein 33

1

1

High-throughput

0.439

High

105906

APRIO
Alternative prion protein

1

8

High-throughput

0.437

High

1119790

NRBP2
Nuclear receptor-binding protein 2

1

7

High-throughput

0.437

High

371990

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.407

High

176299

ZBT39
Zinc finger and BTB domain-containing protein 39

2

0

High-throughput

0.316

High

1119735

CC184
Coiled-coil domain-containing protein 184

2

0

High-throughput

0.316

High

1119737

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

2

0

High-throughput

0.316

High

1119742

ZN474
Zinc finger protein 474

2

0

High-throughput

0.316

High

1119743

ZN620
Zinc finger protein 620

2

0

High-throughput

0.316

High

1119745

ZN572
Zinc finger protein 572

2

0

High-throughput

0.316

High

1119764

ZN526
Zinc finger protein 526

2

0

High-throughput

0.316

High

1119765

MB3L1
Methyl-CpG-binding domain protein 3-like 1

2

0

High-throughput

0.316

High

1119798

SRTD3
SERTA domain-containing protein 3

2

0

High-throughput

0.316

High

1119801

ZN835
Zinc finger protein 835

2

0

High-throughput

0.316

High

1055599

GABPA
GA-binding protein alpha chain

2

0

Small-scale

0.305

High

938345

NH2L1
NHP2-like protein 1

1

0

High-throughput

0.269

Low

761

A0A087WZT3
BOLA2-SMG1P6 readthrough

1

0

High-throughput

0.268

Low

47329

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

903154

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025