HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: TRI25 (Q14258)
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)
Gene: TRIM25

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	37827155, 24399297
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0046872 - metal ion binding
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 630
+	Hs
		651174 RFA1_HUMAN (1-616): 0: 781: 100.00		TRI14_HUMAN (155-624): 1.74e-75: 249: 18.45
+	Hs
		651514 RFA1_HUMAN (1-616): 0: 781: 100.00		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		652113 RFA1_HUMAN (1-616): 0: 781: 100.00		FSD1_HUMAN (196-628): 3.48e-57: 202: 19.30