HitPredict

Interactor 1: IF4B (P23588)
Eukaryotic translation initiation factor 4B (eIF-4B)
Gene: EIF4B

Interactor 2: IF4A1 (P60842)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: EIF4A1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	39358380, 29395067
Identification Methods	cross-linking study, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003743 - translation initiation factor activity GO:0005829 - cytosol GO:0016281 - eukaryotic translation initiation factor 4F complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 611 Hs			1 406
+	Hs
		660627 IF4B_HUMAN (1-611): 5.66e-98: 313: 100.00		IF4A2_HUMAN (4-406): 4.3e-158: 453: 90.32
+	Hs
		660543 IF4B_HUMAN (1-611): 5.66e-98: 313: 100.00		IF4A3_HUMAN (1-406): 1.46e-132: 388: 66.75
+	Sc
		518253 IF4B_YEAST (86-249): 9.39e-31: 126: 20.59		IF4A_YEAST (20-406): 8.05e-168: 477: 66.41
+	Hs
		550282 PABP1_HUMAN (49-545): 1.61e-25: 113: 10.58		IF4A2_HUMAN (4-406): 4.3e-158: 453: 90.32
+	Hs
		1101952 PABP4_HUMAN (49-389): 2.91e-22: 103: 9.72		IF4A2_HUMAN (4-406): 4.3e-158: 453: 90.32
+	Mm
		528909 IF4H_MOUSE (83-245): 8e-39: 145: 33.13		IF4A2_MOUSE (4-406): 1.06e-134: 393: 90.32
+	Hs
		807429 IF4H_HUMAN (83-245): 1.62e-38: 144: 33.13		IF4A3_HUMAN (1-406): 1.46e-132: 388: 66.75
+	Mm
		954061 IF4H_MOUSE (83-245): 8e-39: 145: 33.13		IF4A1_MOUSE (1-406): 9.4e-131: 383: 100.00
+	Hs
		953894 IF4H_HUMAN (83-245): 1.62e-38: 144: 33.13		IF4A1_HUMAN (1-406): 9.4e-131: 383: 100.00
+	Hs
		550156 PABP1_HUMAN (49-545): 1.61e-25: 113: 10.58		IF4A3_HUMAN (1-406): 1.46e-132: 388: 66.75
+	Hs
		550200 PABP1_HUMAN (49-545): 1.61e-25: 113: 10.58		IF4A1_HUMAN (1-406): 9.4e-131: 383: 100.00
+	Hs
		953872 PABP4_HUMAN (49-389): 2.91e-22: 103: 9.72		IF4A1_HUMAN (1-406): 9.4e-131: 383: 100.00
+	Sc
		666407 NSR1_YEAST (84-187): 1.96e-10: 65.3: 20.00		DBP2_YEAST (2-404): 2.8e-135: 400: 31.63
+	Sc
		403516 PABP_YEAST (7-185): 9.64e-24: 107: 16.58		DHH1_YEAST (32-402): 1.42e-99: 307: 44.47
+	Hs
		550126 PABP1_HUMAN (49-545): 1.61e-25: 113: 10.58		DDX6_HUMAN (32-402): 1.67e-88: 278: 38.71
+	Hs
		684388 PABP3_HUMAN (54-547): 6.18e-23: 105: 11.07		DDX6_HUMAN (32-402): 1.67e-88: 278: 38.71
+	Hs
		684225 PABP4_HUMAN (49-389): 2.91e-22: 103: 9.72		DDX6_HUMAN (32-402): 1.67e-88: 278: 38.71