HitPredict

Interactor 1: IF4A3 (P38919)
Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]
Gene: EIF4A3

Interactor 2: IF4H (Q15056)
Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein)
Gene: EIF4H

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	39358380
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 411 Hs			1 248
+	Hs
		953894 IF4A1_HUMAN (7-411): 1.4e-178: 505: 66.75		IF4H_HUMAN (1-248): 3.06e-48: 161: 100.00
+	Mm
		954061 IF4A1_MOUSE (7-411): 1.4e-178: 505: 66.75		IF4H_MOUSE (1-248): 4.61e-48: 161: 98.79
+	Mm
		528909 IF4A2_MOUSE (20-411): 3.43e-177: 501: 69.47		IF4H_MOUSE (1-248): 4.61e-48: 161: 98.79
+	Mm
		915269 IF4A1_MOUSE (7-411): 1.4e-178: 505: 66.75		TIA1_MOUSE (36-231): 8.23e-34: 127: 13.64
+	Hs
		660569 IF4A1_HUMAN (7-411): 1.4e-178: 505: 66.75		IF4B_HUMAN (33-208): 3.58e-31: 122: 32.78
+	Hs
		660627 IF4A2_HUMAN (20-411): 3.43e-177: 501: 69.47		IF4B_HUMAN (33-208): 3.58e-31: 122: 32.78
+	Hs
		550200 IF4A1_HUMAN (7-411): 1.4e-178: 505: 66.75		PABP1_HUMAN (33-237): 3.61e-27: 111: 14.49
+	Hs
		550282 IF4A2_HUMAN (20-411): 3.43e-177: 501: 69.47		PABP1_HUMAN (33-237): 3.61e-27: 111: 14.49
+	At
		102087 F4JEL4_ARATH (1-389): 4.26e-180: 509: 65.47		RBG7_ARATH (37-117): 2.56e-26: 102: 24.10
+	Hs
		953872 IF4A1_HUMAN (7-411): 1.4e-178: 505: 66.75		PABP4_HUMAN (33-219): 3.99e-24: 102: 13.54
+	Hs
		1101952 IF4A2_HUMAN (20-411): 3.43e-177: 501: 69.47		PABP4_HUMAN (33-219): 3.99e-24: 102: 13.54
+	Hs
		953884 IF4A1_HUMAN (7-411): 1.4e-178: 505: 66.75		RBM39_HUMAN (21-248): 5.32e-22: 96.3: 13.10
+	Hs
		660543 IF4A3_HUMAN (1-411): 1.51e-142: 413: 100.00		IF4B_HUMAN (33-208): 3.58e-31: 122: 32.78
+	Mm
		915325 Q8BTS0_MOUSE (25-411): 1.04e-133: 398: 30.63		TIA1_MOUSE (36-231): 8.23e-34: 127: 13.64
+	Hs
		550156 IF4A3_HUMAN (1-411): 1.51e-142: 413: 100.00		PABP1_HUMAN (33-237): 3.61e-27: 111: 14.49
+	Mm
		915297 DDX17_MOUSE (14-411): 1.2e-132: 397: 30.79		TIA1_MOUSE (36-231): 8.23e-34: 127: 13.64
+	Hs
		807418 IF4A3_HUMAN (1-411): 1.51e-142: 413: 100.00		RBM39_HUMAN (21-248): 5.32e-22: 96.3: 13.10
+	Hs
		608597 DDX5_HUMAN (25-411): 9.7e-134: 398: 30.63		RBM39_HUMAN (21-248): 5.32e-22: 96.3: 13.10
+	Hs
		1127053 DDX17_HUMAN (14-411): 7.29e-132: 397: 30.79		RBM39_HUMAN (21-248): 5.32e-22: 96.3: 13.10
+	Mm
		1000097 DDX5_MOUSE (25-411): 8.71e-134: 398: 30.63		TIAR_MOUSE (35-179): 3.12e-14: 73.2: 10.88