HitPredict

Interactor 1: IF4B (P23588)
Eukaryotic translation initiation factor 4B (eIF-4B)
Gene: EIF4B

Interactor 2: IF4A2 (Q14240)
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
Gene: EIF4A2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29395067
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003743 - translation initiation factor activity GO:0005829 - cytosol GO:0006446 - regulation of translational initiation GO:0016281 - eukaryotic translation initiation factor 4F complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 611 Hs			1 407
+	Hs
		660569 IF4B_HUMAN (1-611): 5.66e-98: 313: 100.00		IF4A1_HUMAN (3-407): 1.31e-159: 457: 89.88
+	Hs
		141326 IF4B_HUMAN (1-611): 5.66e-98: 313: 100.00		DDX3X_HUMAN (2-406): 1.08e-126: 382: 29.51
+	Hs
		193085 IF4B_HUMAN (1-611): 5.66e-98: 313: 100.00		DDX3Y_HUMAN (2-406): 1.05e-126: 382: 29.98
+	Hs
		660543 IF4B_HUMAN (1-611): 5.66e-98: 313: 100.00		IF4A3_HUMAN (3-407): 4.46e-129: 379: 67.65
+	Mm
		954061 IF4H_MOUSE (83-245): 8e-39: 145: 33.13		IF4A1_MOUSE (3-407): 1.31e-159: 457: 89.88
+	Hs
		953894 IF4H_HUMAN (83-245): 1.62e-38: 144: 33.13		IF4A1_HUMAN (3-407): 1.31e-159: 457: 89.88
+	Sc
		518253 IF4B_YEAST (86-249): 9.39e-31: 126: 20.59		IF4A_YEAST (24-407): 7.03e-167: 474: 65.89
+	Hs
		550200 PABP1_HUMAN (49-545): 1.61e-25: 113: 10.58		IF4A1_HUMAN (3-407): 1.31e-159: 457: 89.88
+	Hs
		953872 PABP4_HUMAN (49-389): 2.91e-22: 103: 9.72		IF4A1_HUMAN (3-407): 1.31e-159: 457: 89.88
+	Hs
		807429 IF4H_HUMAN (83-245): 1.62e-38: 144: 33.13		IF4A3_HUMAN (3-407): 4.46e-129: 379: 67.65
+	Mm
		528909 IF4H_MOUSE (83-245): 8e-39: 145: 33.13		IF4A2_MOUSE (1-407): 1.73e-128: 377: 100.00
+	Hs
		141299 PABP1_HUMAN (49-545): 1.61e-25: 113: 10.58		DDX3X_HUMAN (2-406): 1.08e-126: 382: 29.51
+	Hs
		550156 PABP1_HUMAN (49-545): 1.61e-25: 113: 10.58		IF4A3_HUMAN (3-407): 4.46e-129: 379: 67.65
+	Hs
		550282 PABP1_HUMAN (49-545): 1.61e-25: 113: 10.58		IF4A2_HUMAN (1-407): 1.73e-128: 377: 100.00
+	Hs
		141463 PABP4_HUMAN (49-389): 2.91e-22: 103: 9.72		DDX3X_HUMAN (2-406): 1.08e-126: 382: 29.51
+	Hs
		1101952 PABP4_HUMAN (49-389): 2.91e-22: 103: 9.72		IF4A2_HUMAN (1-407): 1.73e-128: 377: 100.00
+	Sc
		666407 NSR1_YEAST (84-187): 1.96e-10: 65.3: 20.00		DBP2_YEAST (22-405): 1.02e-131: 390: 32.65
+	Sc
		403516 PABP_YEAST (7-185): 9.64e-24: 107: 16.58		DHH1_YEAST (33-403): 1.14e-98: 305: 43.67