Interactor 1: NOS2 (P29477)
Nitric oxide synthase, inducible (EC 1.14.13.39) (Inducible NO synthase) (Inducible NOS) (iNOS) (Macrophage NOS) (MAC-NOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)
Gene: NOS2

Interactor 2: NOS2 (P29477)
Nitric oxide synthase, inducible (EC 1.14.13.39) (Inducible NO synthase) (Inducible NOS) (iNOS) (Macrophage NOS) (MAC-NOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)
Gene: NOS2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.55 1.00 0.744

The method score is based on:

Property Details
Experiments 8995432, 12437348
Identification Methods two hybrid, x-ray crystallography
Interaction Type direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains FAD_binding_1~FAD_binding_1, FAD_binding_1~Flavodoxin_1, FAD_binding_1~NAD_binding_1, Flavodoxin_1~Flavodoxin_1, Flavodoxin_1~NAD_binding_1, NAD_binding_1~NAD_binding_1, NO_synthase~NO_synthase
Common GO terms GO:0001666 - response to hypoxia
GO:0001974 - blood vessel remodeling
GO:0003779 - actin binding
GO:0004517 - nitric-oxide synthase activity
GO:0005516 - calmodulin binding
and 54 others

more...

Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 1144
Mm

1 1144
+ Hs
+ Hs
+ Hs
+ Bt
+ Hs
+ Dm
+ Hs
+ Hs
+ Ec
+ Pf

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Last updated: 15 Jul 2024