HitPredict

Interactor 1: RPB2 (P30876)
DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48)
Gene: POLR2B

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34662580
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1174 Hs			1 757
+	Hs
		676969 RPB2_HUMAN (1-1174): 0: 1704: 100.00		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		125179 RPB2_HUMAN (1-1174): 0: 1704: 100.00		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		676831 RPB2_HUMAN (1-1174): 0: 1704: 100.00		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Sc
		440039 RPB2_YEAST (4-1173): 0: 1472: 58.05		RSP5_YEAST (13-757): 0: 712: 36.40
+	Sc
		440089 RPB2_YEAST (4-1173): 0: 1472: 58.05		TOM1_YEAST (267-756): 5.63e-161: 518: 33.94
+	Hs
		676997 RPB2_HUMAN (1-1174): 0: 1704: 100.00		WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94
+	Hs
		677041 RPB2_HUMAN (1-1174): 0: 1704: 100.00		HECW2_HUMAN (1-322): 1.89e-15: 82.9: 14.87
+	Sc
		604605 RPA2_YEAST (31-1170): 0: 1105: 26.64		TOM1_YEAST (267-756): 5.63e-161: 518: 33.94