HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: KSR1 (Q8IVT5)
Kinase suppressor of Ras 1 (EC 2.7.11.1)
Gene: KSR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.932

Property	Details
Experiments	33961781, 35271311, 36931259, 24255178, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 923
+	Hs
		909779 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KSR1_HUMAN (1-923): 0: 765: 100.00
+	Mm
		910254 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		KSR1_MOUSE (1-923): 0: 715: 84.42
+	Mm
		926799 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		KSR1_MOUSE (1-923): 0: 715: 84.42
+	Hs
		909702 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KSR2_HUMAN (33-898): 0: 577: 45.45
+	Hs
		683466 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KSR2_HUMAN (33-898): 0: 577: 45.45
+	At
		248524 14331_ARATH (2-240): 2.71e-143: 403: 62.96		SIRK_ARATH (96-881): 1.27e-164: 505: 12.92
+	Hs
		46556 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		A0A2R8Y8E0_HUMAN (252-914): 6.43e-152: 470: 23.19
+	Hs
		110869 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		H7C560_HUMAN (252-914): 9.21e-149: 460: 22.80
+	Hs
		542849 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		BRAF_HUMAN (252-914): 2.03e-148: 459: 22.80
+	Hs
		542827 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		BRAF_HUMAN (252-914): 2.03e-148: 459: 22.80
+	Mm
		655938 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		BRAF_MOUSE (252-914): 2.44e-148: 458: 22.95
+	Hs
		488645 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		ARAF_HUMAN (261-899): 1.38e-148: 454: 24.55
+	Hs
		488590 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		ARAF_HUMAN (261-899): 1.38e-148: 454: 24.55
+	Mm
		655943 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		BRAF_MOUSE (252-914): 2.44e-148: 458: 22.95
+	Gg
		982842 1433E_CHICK (3-243): 4.39e-144: 405: 65.43		BRAF_CHICK (252-914): 3.87e-145: 450: 23.10
+	Hs
		373995 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		373771 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Mm
		926872 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		RAF1_MOUSE (232-908): 1.01e-140: 435: 22.40
+	Dm
		507708 1433E_DROME (3-245): 4.63e-144: 405: 64.90		KRAF1_DROME (251-908): 5.23e-117: 376: 20.48
+	Hs
		411661 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59