HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: P55G (Q92569)
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
Gene: PIK3R3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 461
+	Hs
		699676 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		P85A_HUMAN (48-455): 1.82e-102: 323: 79.41
+	Hs
		699687 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		P85A_HUMAN (48-455): 1.82e-102: 323: 79.41
+	Mm
		686947 RAC1_MOUSE (1-193): 7e-79: 235: 57.22		P85A_MOUSE (60-455): 4.29e-101: 319: 81.06
+	Hs
		136355 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		P85B_HUMAN (56-453): 1.57e-98: 313: 74.12
+	Hs
		136363 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		P85B_HUMAN (56-453): 1.57e-98: 313: 74.12
+	Hs
		840944 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		ABL2_HUMAN (301-459): 1.22e-23: 106: 23.93
+	Hs
		440473 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		FYN_HUMAN (323-459): 5.41e-23: 103: 25.52
+	Hs
		440481 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		FYN_HUMAN (323-459): 5.41e-23: 103: 25.52
+	Hs
		463043 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		YES_HUMAN (308-459): 1.96e-21: 98.9: 22.36
+	Hs
		463050 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		YES_HUMAN (308-459): 1.96e-21: 98.9: 22.36
+	Hs
		463434 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		LYN_HUMAN (245-458): 1.18e-20: 96.5: 19.91
+	Hs
		841004 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		FRK_HUMAN (256-459): 3.4e-21: 98.1: 24.04
+	Hs
		557206 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		SRC_HUMAN (324-459): 7.1e-21: 97.3: 24.31
+	Hs
		463442 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		LYN_HUMAN (245-458): 1.18e-20: 96.5: 19.91
+	Hs
		962621 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		VAV3_HUMAN (44-159): 6.84e-16: 82.5: 30.17
+	Ce
		1041913 RAC1_CAEEL (1-193): 1.28e-79: 236: 55.44		VAV_CAEEL (336-451): 2.11e-14: 77.9: 26.72
+	Hs
		913634 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		VAV2_HUMAN (38-159): 4.48e-13: 73.7: 22.95
+	Hs
		913637 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		VAV2_HUMAN (38-159): 4.48e-13: 73.7: 22.95
+	Hs
		584505 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		VAV_HUMAN (65-170): 4.02e-12: 70.6: 27.36
+	Hs
		584511 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		VAV_HUMAN (65-170): 4.02e-12: 70.6: 27.36