HitPredict

Interactor 1: VDAC1 (P21796)
Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM)
Gene: VDAC1

Interactor 2: RAB7A (P51149)
Ras-related protein Rab-7a (EC 3.6.5.2)
Gene: RAB7A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26496610, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005886 - plasma membrane GO:0031966 - mitochondrial membrane GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 283 Hs			1 207
+	Hs
		799962 VDAC2_HUMAN (1-283): 4.13e-118: 342: 74.56		RAB1A_HUMAN (1-206): 7.27e-87: 256: 33.50
+	Hs
		799950 VDAC2_HUMAN (1-283): 4.13e-118: 342: 74.56		RAB7A_HUMAN (1-207): 5.09e-80: 239: 100.00
+	Hs
		601201 VDAC1_HUMAN (1-283): 1.37e-110: 322: 100.00		RAB1A_HUMAN (1-206): 7.27e-87: 256: 33.50
+	Hs
		601361 VDAC1_HUMAN (1-283): 1.37e-110: 322: 100.00		RAB1B_HUMAN (1-205): 2.14e-86: 255: 34.15
+	Hs
		918970 VDAC3_HUMAN (1-283): 1.29e-105: 310: 67.49		RAB1A_HUMAN (1-206): 7.27e-87: 256: 33.50
+	Sc
		389876 VDAC1_YEAST (4-283): 7.73e-78: 239: 24.74		YPT7_YEAST (1-207): 3.66e-81: 242: 61.79
+	Hs
		799949 VDAC2_HUMAN (1-283): 4.13e-118: 342: 74.56		RAB5C_HUMAN (9-179): 1.56e-37: 131: 42.44
+	Hs
		601178 VDAC1_HUMAN (1-283): 1.37e-110: 322: 100.00		RAB5C_HUMAN (9-179): 1.56e-37: 131: 42.44
+	Hs
		330656 TOM40_HUMAN (4-279): 5.43e-60: 196: 12.46		RAB1A_HUMAN (1-206): 7.27e-87: 256: 33.50
+	Hs
		330722 TOM40_HUMAN (4-279): 5.43e-60: 196: 12.46		RAB1B_HUMAN (1-205): 2.14e-86: 255: 34.15
+	Hs
		330644 TOM40_HUMAN (4-279): 5.43e-60: 196: 12.46		RAB7A_HUMAN (1-207): 5.09e-80: 239: 100.00