HitPredict

Interactor 1: P85A (P26450)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: Pik3r1

Interactor 2: EPS8 (Q08509)
Epidermal growth factor receptor kinase substrate 8
Gene: EPS8

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12515821
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RhoGAP~SH3_1, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Mm			1 821
+	Mm
		686943 P85A_MOUSE (1-724): 0: 564: 100.00		CRKL_MOUSE (506-703): 1.84e-40: 153: 18.93
+	Mm
		686974 P85A_MOUSE (1-724): 0: 564: 100.00		CRK_MOUSE (394-701): 8.35e-39: 148: 11.00
+	Hs
		699643 P85A_HUMAN (1-724): 0: 553: 94.35		CRKL_HUMAN (506-703): 9.27e-40: 151: 18.45
+	Hs
		699642 P85A_HUMAN (1-724): 0: 553: 94.35		CRK_HUMAN (394-701): 7.23e-39: 148: 11.00
+	Mm
		686941 P85A_MOUSE (1-724): 0: 564: 100.00		FYN_MOUSE (455-593): 4.03e-30: 127: 16.31
+	Hs
		462996 P85A_HUMAN (1-724): 0: 553: 94.35		YES_HUMAN (449-593): 5.24e-31: 130: 20.00
+	Hs
		440388 P85A_HUMAN (1-724): 0: 553: 94.35		FYN_HUMAN (455-593): 1.73e-30: 128: 16.31
+	Mm
		686939 P85A_MOUSE (1-724): 0: 564: 100.00		BTK_MOUSE (490-588): 7.94e-24: 109: 16.98
+	Hs
		699655 P85A_HUMAN (1-724): 0: 553: 94.35		BLK_HUMAN (495-591): 7.45e-25: 111: 23.47
+	Hs
		699767 P85A_HUMAN (1-724): 0: 553: 94.35		ITSN1_HUMAN (401-760): 4.75e-24: 111: 9.39
+	Hs
		593920 P85A_HUMAN (1-724): 0: 553: 94.35		NCK1_HUMAN (487-737): 5.09e-22: 100: 10.07
+	Mm
		593626 P85A_MOUSE (1-724): 0: 564: 100.00		BLK_MOUSE (492-594): 1.55e-10: 66.5: 21.15
+	Mm
		148479 P85B_MOUSE (3-723): 1.91e-155: 469: 56.91		CRK_MOUSE (394-701): 8.35e-39: 148: 11.00
+	Hs
		136330 P85B_HUMAN (4-719): 7.25e-153: 463: 57.10		CRKL_HUMAN (506-703): 9.27e-40: 151: 18.45
+	Hs
		136329 P85B_HUMAN (4-719): 7.25e-153: 463: 57.10		CRK_HUMAN (394-701): 7.23e-39: 148: 11.00
+	Hs
		136255 P85B_HUMAN (4-719): 7.25e-153: 463: 57.10		FYN_HUMAN (455-593): 1.73e-30: 128: 16.31
+	Hs
		855709 P55G_HUMAN (271-723): 3.1e-91: 294: 72.31		CRK_HUMAN (394-701): 7.23e-39: 148: 11.00
+	Hs
		463181 P55G_HUMAN (271-723): 3.1e-91: 294: 72.31		YES_HUMAN (449-593): 5.24e-31: 130: 20.00
+	Hs
		440656 P55G_HUMAN (271-723): 3.1e-91: 294: 72.31		FYN_HUMAN (455-593): 1.73e-30: 128: 16.31
+	Hs
		594065 P55G_HUMAN (271-723): 3.1e-91: 294: 72.31		NCK1_HUMAN (487-737): 5.09e-22: 100: 10.07