HitPredict

Interactor 1: 1433Z (P29310)
14-3-3 protein zeta (14-3-3-like protein) (Protein Leonardo)
Gene: 14-3-3zeta

Interactor 2: Q9VCC9 (Q9VCC9)
LD23779p (Tsc1)
Gene: Tsc1

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	22068330, 27626673
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction GO:0035332 - positive regulation of hippo signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Dm			1 1100
+	Dm
		1019899 1433E_DROME (4-248): 2.9e-143: 403: 65.18		Q9VCC9_DROME (1-1077): 0: 728: 100.00
+	Hs
		971839 1433E_HUMAN (5-246): 4.92e-144: 404: 66.80		TSC1_HUMAN (3-969): 0: 564: 21.07
+	Hs
		730108 1433B_HUMAN (3-247): 2.06e-143: 403: 78.78		TSC1_HUMAN (3-969): 0: 564: 21.07
+	Mm
		972314 1433E_MOUSE (5-246): 4.92e-144: 404: 66.80		TSC1_MOUSE (3-969): 5.9e-176: 548: 21.96
+	Hs
		244134 1433B_HUMAN (3-247): 2.06e-143: 403: 78.78		KIF5C_HUMAN (440-949): 7.76e-40: 162: 14.31
+	Hs
		244133 1433T_HUMAN (4-248): 4.05e-143: 402: 77.14		KIF5C_HUMAN (440-949): 7.76e-40: 162: 14.31
+	Hs
		749891 1433E_HUMAN (5-246): 4.92e-144: 404: 66.80		KINH_HUMAN (471-955): 8.33e-37: 152: 13.64
+	Hs
		729639 1433B_HUMAN (3-247): 2.06e-143: 403: 78.78		KINH_HUMAN (471-955): 8.33e-37: 152: 13.64
+	Hs
		690771 1433T_HUMAN (4-248): 4.05e-143: 402: 77.14		KINH_HUMAN (471-955): 8.33e-37: 152: 13.64
+	Mm
		749844 1433E_MOUSE (5-246): 4.92e-144: 404: 66.80		KIF5A_MOUSE (485-1070): 1.77e-33: 141: 12.28
+	Hs
		971455 1433E_HUMAN (5-246): 4.92e-144: 404: 66.80		KIF5A_HUMAN (485-1070): 1.25e-31: 136: 12.42
+	Hs
		729786 1433B_HUMAN (3-247): 2.06e-143: 403: 78.78		KIF5A_HUMAN (485-1070): 1.25e-31: 136: 12.42
+	Hs
		773148 1433E_HUMAN (5-246): 4.92e-144: 404: 66.80		MYH10_HUMAN (557-1092): 1.36e-20: 101: 9.69
+	Hs
		776794 1433E_HUMAN (5-246): 4.92e-144: 404: 66.80		MYH11_HUMAN (618-1100): 1.18e-20: 101: 10.95
+	Hs
		690788 1433T_HUMAN (4-248): 4.05e-143: 402: 77.14		MYH11_HUMAN (618-1100): 1.18e-20: 101: 10.95
+	Hs
		690784 1433T_HUMAN (4-248): 4.05e-143: 402: 77.14		MYH9_HUMAN (392-1041): 2.8e-20: 99.6: 11.08
+	Hs
		971623 1433E_HUMAN (5-246): 4.92e-144: 404: 66.80		MRCKA_HUMAN (762-1099): 1.78e-18: 93.7: 10.47
+	Hs
		729924 1433B_HUMAN (3-247): 2.06e-143: 403: 78.78		MRCKA_HUMAN (762-1099): 1.78e-18: 93.7: 10.47
+	Hs
		556897 1433T_HUMAN (4-248): 4.05e-143: 402: 77.14		MYH7_HUMAN (593-1100): 4.43e-18: 92.5: 12.93
+	Mm
		972233 1433E_MOUSE (5-246): 4.92e-144: 404: 66.80		KINH_MOUSE (623-952): 6.02e-11: 69.1: 12.88