HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: STYX (Q8WUJ0)
Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein)
Gene: STYX

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DSPc~fn3
Common GO terms	GO:0070372 - regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 223
+	Hs
		1147391 EPHA7_HUMAN (4-974): 0: 1120: 50.15		STYX_HUMAN (1-223): 3.2e-91: 268: 100.00
+	Hs
		710646 EPHA3_HUMAN (24-976): 0: 1096: 50.98		STYX_HUMAN (1-223): 3.2e-91: 268: 100.00
+	Hs
		326661 EPHA2_HUMAN (1-976): 0: 1124: 100.00		DUS14_HUMAN (7-185): 1.9e-63: 197: 31.84
+	Hs
		710370 EPHA2_HUMAN (1-976): 0: 1124: 100.00		DUS18_HUMAN (10-185): 1.36e-58: 184: 26.71
+	Hs
		1147384 EPHA7_HUMAN (4-974): 0: 1120: 50.15		DUS18_HUMAN (10-185): 1.36e-58: 184: 26.71
+	Hs
		710303 EPHA2_HUMAN (1-976): 0: 1124: 100.00		DUS29_HUMAN (22-174): 1.12e-56: 180: 30.77
+	Hs
		710456 EPHA2_HUMAN (1-976): 0: 1124: 100.00		DUS26_HUMAN (27-176): 7.86e-57: 180: 30.46
+	Hs
		710392 EPHA2_HUMAN (1-976): 0: 1124: 100.00		DUS19_HUMAN (32-187): 3.45e-55: 177: 33.97
+	Hs
		1147419 EPHA7_HUMAN (4-974): 0: 1120: 50.15		DUS26_HUMAN (27-176): 7.86e-57: 180: 30.46
+	Hs
		931897 EPHA5_HUMAN (11-976): 0: 1115: 51.34		DUS21_HUMAN (19-185): 3.02e-55: 176: 26.95
+	Hs
		710641 EPHA3_HUMAN (24-976): 0: 1096: 50.98		DUS18_HUMAN (10-185): 1.36e-58: 184: 26.71
+	Hs
		710661 EPHA3_HUMAN (24-976): 0: 1096: 50.98		DUS21_HUMAN (19-185): 3.02e-55: 176: 26.95
+	Hs
		326657 EPHA1_HUMAN (17-967): 0: 947: 49.28		DUS14_HUMAN (7-185): 1.9e-63: 197: 31.84
+	Hs
		181807 EPHB6_HUMAN (28-962): 0: 869: 37.40		STYX_HUMAN (1-223): 3.2e-91: 268: 100.00
+	Hs
		181804 EPHB6_HUMAN (28-962): 0: 869: 37.40		DUS18_HUMAN (10-185): 1.36e-58: 184: 26.71
+	Hs
		181806 EPHB6_HUMAN (28-962): 0: 869: 37.40		DUS19_HUMAN (32-187): 3.45e-55: 177: 33.97
+	Hs
		572947 INSRR_HUMAN (287-911): 1.43e-146: 470: 27.55		STYX_HUMAN (1-223): 3.2e-91: 268: 100.00
+	Hs
		326647 INSR_HUMAN (281-911): 2.91e-136: 444: 24.78		DUS14_HUMAN (7-185): 1.9e-63: 197: 31.84
+	Hs
		439793 INSR_HUMAN (281-911): 2.91e-136: 444: 24.78		DUS18_HUMAN (10-185): 1.36e-58: 184: 26.71
+	Hs
		439798 INSR_HUMAN (281-911): 2.91e-136: 444: 24.78		DUS19_HUMAN (32-187): 3.45e-55: 177: 33.97