HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 1116
+	Hs
		1147436 EPHA7_HUMAN (4-974): 0: 1120: 50.15		PKHA5_HUMAN (1-1116): 0: 685: 100.00
+	Hs
		931900 EPHA5_HUMAN (11-976): 0: 1115: 51.34		PKHA5_HUMAN (1-1116): 0: 685: 100.00
+	Hs
		710894 EPHB2_HUMAN (28-973): 0: 1077: 48.29		PKHA5_HUMAN (1-1116): 0: 685: 100.00
+	Hs
		640292 EPHA1_HUMAN (17-967): 0: 947: 49.28		PKHA5_HUMAN (1-1116): 0: 685: 100.00
+	Hs
		710305 EPHA2_HUMAN (1-976): 0: 1124: 100.00		PKHA7_HUMAN (2-1059): 1.41e-137: 446: 27.40
+	Hs
		181825 EPHB6_HUMAN (28-962): 0: 869: 37.40		PKHA5_HUMAN (1-1116): 0: 685: 100.00
+	Hs
		710581 EPHA2_HUMAN (1-976): 0: 1124: 100.00		PKHA6_HUMAN (109-1116): 9.07e-88: 308: 28.41
+	Hs
		710317 EPHA2_HUMAN (1-976): 0: 1124: 100.00		MPRIP_HUMAN (79-765): 7.82e-54: 206: 12.95
+	Hs
		710207 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ANK3_HUMAN (378-1098): 3e-50: 197: 11.71
+	Hs
		710812 EPHB2_HUMAN (28-973): 0: 1077: 48.29		ANK2_HUMAN (261-1106): 2.88e-56: 216: 10.80
+	Hs
		1147437 EPHA7_HUMAN (4-974): 0: 1120: 50.15		PKHA1_HUMAN (113-359): 3.29e-42: 161: 18.49
+	Hs
		931901 EPHA5_HUMAN (11-976): 0: 1115: 51.34		PKHA1_HUMAN (113-359): 3.29e-42: 161: 18.49
+	Hs
		710822 EPHB2_HUMAN (28-973): 0: 1077: 48.29		ANK3_HUMAN (378-1098): 3e-50: 197: 11.71
+	Hs
		932137 EPHA4_HUMAN (1-974): 0: 1110: 50.35		PKHA1_HUMAN (113-359): 3.29e-42: 161: 18.49
+	Hs
		640336 EPHA1_HUMAN (17-967): 0: 947: 49.28		PKHA6_HUMAN (109-1116): 9.07e-88: 308: 28.41
+	Hs
		710427 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ITCH_HUMAN (11-246): 4.77e-29: 127: 16.95
+	Hs
		710895 EPHB2_HUMAN (28-973): 0: 1077: 48.29		PKHA1_HUMAN (113-359): 3.29e-42: 161: 18.49
+	Hs
		181826 EPHB6_HUMAN (28-962): 0: 869: 37.40		PKHA1_HUMAN (113-359): 3.29e-42: 161: 18.49
+	Hs
		720328 UFO_HUMAN (294-911): 1.96e-144: 454: 24.15		PKHA1_HUMAN (113-359): 3.29e-42: 161: 18.49
+	Hs
		720319 UFO_HUMAN (294-911): 1.96e-144: 454: 24.15		WWP1_HUMAN (6-240): 4.44e-23: 108: 15.48