HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: JAK3 (P52333)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Gene: JAK3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.851

Property	Details
Experiments	29991678, 27144517, 29674694, 34989544
Identification Methods	affinity chromatography technology, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0019221 - cytokine-mediated signaling pathway GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 1124
+	Rn
		102468 G3V6B4_RAT (1-211): 9.05e-50: 162: 88.21		JAK2_RAT (4-1101): 0: 910: 48.47
+	Mm
		193352 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		JAK2_MOUSE (4-1101): 0: 897: 48.38
+	Hs
		181748 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		JAK2_HUMAN (7-1101): 0: 889: 47.80
+	Hs
		146668 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		YES_HUMAN (784-1109): 7.17e-99: 326: 29.36
+	Hs
		181753 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ABL1_HUMAN (760-1102): 3.81e-95: 330: 29.48
+	Hs
		181783 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		SRC_HUMAN (793-1109): 4.7e-100: 328: 29.25
+	Hs
		181770 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		YES_HUMAN (784-1109): 7.17e-99: 326: 29.36
+	Hs
		181764 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		LCK_HUMAN (794-1110): 1.37e-97: 321: 30.50
+	Hs
		181765 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FYN_HUMAN (790-1109): 4.99e-97: 320: 29.60
+	Hs
		181866 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ERBB4_HUMAN (822-1104): 2.36e-87: 310: 36.62
+	Hs
		181771 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		LYN_HUMAN (781-1110): 2.14e-92: 307: 28.40
+	Hs
		181824 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		BLK_HUMAN (784-1105): 3.14e-89: 298: 29.63
+	Hs
		181846 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		TIE2_HUMAN (813-1091): 3.45e-39: 160: 33.88
+	Mm
		69806 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		B1ASP2_MOUSE (764-1119): 4.65e-38: 157: 18.25
+	Hs
		181799 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		JAK1_HUMAN (761-1119): 1.21e-38: 158: 18.62
+	Hs
		181802 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		TYK2_HUMAN (828-1122): 5.53e-34: 144: 20.62
+	Hs
		181754 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		256842 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		181758 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ERBB2_HUMAN (527-780): 1.84e-13: 77.4: 25.00
+	Hs
		256843 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ERBB2_HUMAN (527-780): 1.84e-13: 77.4: 25.00