Interactor 1: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1
Interactor 2: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.81 | 1.00 | 0.905 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 11432859, 14634131, 8700869, 27043298, 24630722 |
| Identification Methods | affinity chromatography technology, anti tag coimmunoprecipitation, protease assay, 3D electron microscopy, fluorescence polarization spectroscopy |
| Interaction Type | physical association, protein cleavage, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | CARD~CARD, Peptidase_C14~Peptidase_C14 |
| Common GO terms | GO:0002221 - pattern recognition receptor signaling pathway GO:0004175 - endopeptidase activity GO:0004197 - cysteine-type endopeptidase activity GO:0005730 - nucleolus GO:0005737 - cytoplasm and 37 others more... |
| Homologous interactions | 17 |
Homologous interactions
Color coding for hit scores 
Service provided by Combinatics, Japan
Last updated: 11Aug2025