HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	31577950, 34642328, 21145461
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 840 Hs			1 81
+	Hs
		320860 HS74L_HUMAN (1-840): 0: 959: 63.21		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		1079556 HS105_HUMAN (1-840): 0: 938: 62.95		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Ce
		450538 HSP1_CAEEL (2-603): 0: 811: 31.48		NEDD8_CAEEL (1-77): 7.56e-34: 112: 87.01
+	Hs
		474905 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		504136 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		713983 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		564084 HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00