HitPredict

Interactor 1: CDK4 (P30285)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CDN2B (P55271)
Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b)
Gene: Cdkn2b

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	17713536
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase
Common GO terms	GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 303 Mm			1 130
+	Hs
		842907 CDK6_HUMAN (5-299): 4.48e-128: 369: 68.58		CDN2B_HUMAN (3-130): 2.1e-51: 160: 88.28
+	Hs
		549084 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		CDN2B_HUMAN (3-130): 2.1e-51: 160: 88.28
+	Hs
		842727 CDK6_HUMAN (5-299): 4.48e-128: 369: 68.58		CDN2A_HUMAN (10-129): 2.61e-48: 153: 89.17
+	Hs
		549083 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		CDN2A_HUMAN (10-129): 2.61e-48: 153: 89.17
+	Mm
		718969 CDK4_MOUSE (1-303): 3.21e-128: 368: 100.00		CDN2A_MOUSE (16-128): 4.56e-45: 145: 70.80
+	Hs
		668005 CDK2_HUMAN (3-301): 1.28e-145: 412: 43.56		BARD1_HUMAN (35-129): 5.99e-21: 88.9: 27.08
+	Mm
		718975 CDK4_MOUSE (1-303): 3.21e-128: 368: 100.00		CDN2C_MOUSE (10-129): 1.43e-35: 121: 42.50
+	Hs
		842952 CDK6_HUMAN (5-299): 4.48e-128: 369: 68.58		CDN2C_HUMAN (10-129): 7.52e-34: 117: 42.50
+	Hs
		549085 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		CDN2C_HUMAN (10-129): 7.52e-34: 117: 42.50
+	Hs
		295450 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		PSD10_HUMAN (14-130): 2.38e-29: 107: 22.69
+	Hs
		668052 CDK2_HUMAN (3-301): 1.28e-145: 412: 43.56		RAI14_HUMAN (76-130): 1.04e-09: 56.9: 23.21
+	Hs
		443493 CDK1_HUMAN (3-300): 2.26e-130: 374: 42.24		BARD1_HUMAN (35-129): 5.99e-21: 88.9: 27.08
+	Mm
		718983 CDK4_MOUSE (1-303): 3.21e-128: 368: 100.00		PSD10_MOUSE (45-129): 9.7e-18: 77.3: 16.47
+	Hs
		443480 CDK1_HUMAN (3-300): 2.26e-130: 374: 42.24		ANR27_HUMAN (11-129): 2.3e-14: 70: 17.91
+	Mm
		1221474 CDK6_MOUSE (5-303): 4.51e-129: 372: 67.67		CDN2D_MOUSE (4-127): 3.34e-09: 53.8: 24.19
+	Hs
		937461 CDK6_HUMAN (5-299): 4.48e-128: 369: 68.58		CDN2D_HUMAN (5-94): 7.45e-10: 55.3: 27.47
+	Hs
		549110 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		CDN2D_HUMAN (5-94): 7.45e-10: 55.3: 27.47
+	Mm
		718976 CDK4_MOUSE (1-303): 3.21e-128: 368: 100.00		CDN2D_MOUSE (4-127): 3.34e-09: 53.8: 24.19