HitPredict

Interactor 1: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Interactor 2: CDK6 (Q00534)
Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
Gene: CDK6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.768

The method score is based on:

Property Details
Experiments 26186194, 28514442, 9751050, 11739795, 33961781, 32707033, 34568836, 9380698, 17909018, 23602568, 8805225, 10022865, 28205554, 35271311, 37626264, 17881001, 10491434, 11556834, 15232106, 17955473 and 1 others

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Identification Methods affinity chromatography technology, x-ray crystallography, pull down, enzymatic study, unspecified method, fluorescent resonance energy transfer, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein array, tandem affinity purification
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008285 - negative regulation of cell population proliferation
and 1 others

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Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 156
Hs

1 326
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Last updated: 11Aug2025