HitPredict

Interactor 1: CDK4 (P30285)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CDN2C (Q60772)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: Cdkn2c

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	17713536
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 303 Mm			1 168
+	Hs
		668052 CDK2_HUMAN (3-301): 1.28e-145: 412: 43.56		RAI14_HUMAN (1-135): 1.13e-36: 135: 23.53
+	Hs
		842952 CDK6_HUMAN (5-299): 4.48e-128: 369: 68.58		CDN2C_HUMAN (1-168): 2.12e-52: 165: 92.26
+	Hs
		549085 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		CDN2C_HUMAN (1-168): 2.12e-52: 165: 92.26
+	Mm
		1221474 CDK6_MOUSE (5-303): 4.51e-129: 372: 67.67		CDN2D_MOUSE (6-161): 1.35e-46: 151: 44.59
+	Mm
		718976 CDK4_MOUSE (1-303): 3.21e-128: 368: 100.00		CDN2D_MOUSE (6-161): 1.35e-46: 151: 44.59
+	Hs
		937461 CDK6_HUMAN (5-299): 4.48e-128: 369: 68.58		CDN2D_HUMAN (6-162): 7.21e-46: 149: 43.67
+	Hs
		549110 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		CDN2D_HUMAN (6-162): 7.21e-46: 149: 43.67
+	Hs
		295450 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		PSD10_HUMAN (1-110): 2.05e-30: 111: 25.23
+	Mm
		718983 CDK4_MOUSE (1-303): 3.21e-128: 368: 100.00		PSD10_MOUSE (1-110): 3.62e-30: 111: 25.23
+	Hs
		842727 CDK6_HUMAN (5-299): 4.48e-128: 369: 68.58		CDN2A_HUMAN (3-140): 1.68e-22: 89.4: 40.29
+	Hs
		549083 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		CDN2A_HUMAN (3-140): 1.68e-22: 89.4: 40.29
+	Hs
		842907 CDK6_HUMAN (5-299): 4.48e-128: 369: 68.58		CDN2B_HUMAN (9-127): 1.38e-21: 86.7: 45.00
+	Mm
		718971 CDK4_MOUSE (1-303): 3.21e-128: 368: 100.00		CDN2B_MOUSE (9-127): 7.87e-22: 87: 43.33
+	Hs
		549084 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		CDN2B_HUMAN (9-127): 1.38e-21: 86.7: 45.00
+	Mm
		718969 CDK4_MOUSE (1-303): 3.21e-128: 368: 100.00		CDN2A_MOUSE (15-122): 2.58e-20: 84: 44.04
+	Hs
		1025481 CDK5_HUMAN (3-301): 6.07e-125: 360: 43.75		MIB1_HUMAN (74-168): 4.9e-14: 70.7: 23.96