HitPredict

Interactor 1: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Interactor 2: CDK6 (Q00534)
Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
Gene: CDK6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 25910212, 28514442, 17353931, 27107012, 10022865, 28205554, 8001816, 33961781, 25416956, 26186194, 12370184, 32296183, 11124804, 32707033, 34568836, 23602568, 31515488, unassigned1304, 18394558, 25502805 and 1 others

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Identification Methods two hybrid, affinity chromatography technology, pull down, fluorescent resonance energy transfer, x-ray crystallography, two hybrid prey pooling approach, two hybrid array, anti bait coimmunoprecipitation, barcode fusion genetics two hybrid, split luciferase complementation and 4 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008285 - negative regulation of cell population proliferation
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 168
Hs

1 326
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Service provided by Combinatics, Japan

Last updated: 11Aug2025