HitPredict

Interactor 1: CDK4 (P30285)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CDN2D (Q60773)
Cyclin-dependent kinase 4 inhibitor D (p19-INK4d)
Gene: Cdkn2d

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	7739548
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank~Pkinase, Ank_2~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0097129 - cyclin D2-CDK4 complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 303 Mm			1 166
+	Mm
		1221474 CDK6_MOUSE (5-303): 4.51e-129: 372: 67.67		CDN2D_MOUSE (1-166): 5.86e-55: 172: 100.00
+	Hs
		937461 CDK6_HUMAN (5-299): 4.48e-128: 369: 68.58		CDN2D_HUMAN (1-166): 2.09e-53: 168: 86.75
+	Hs
		549110 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		CDN2D_HUMAN (1-166): 2.09e-53: 168: 86.75
+	Mm
		718975 CDK4_MOUSE (1-303): 3.21e-128: 368: 100.00		CDN2C_MOUSE (9-163): 6.69e-47: 152: 42.68
+	Hs
		842952 CDK6_HUMAN (5-299): 4.48e-128: 369: 68.58		CDN2C_HUMAN (9-163): 5.79e-46: 149: 43.95
+	Hs
		549085 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		CDN2C_HUMAN (9-163): 5.79e-46: 149: 43.95
+	Hs
		668052 CDK2_HUMAN (3-301): 1.28e-145: 412: 43.56		RAI14_HUMAN (1-100): 2.93e-23: 96.9: 23.08
+	Hs
		295450 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		PSD10_HUMAN (48-165): 4.54e-35: 123: 21.67
+	Mm
		718983 CDK4_MOUSE (1-303): 3.21e-128: 368: 100.00		PSD10_MOUSE (48-165): 3.66e-35: 123: 21.67
+	Hs
		842907 CDK6_HUMAN (5-299): 4.48e-128: 369: 68.58		CDN2B_HUMAN (12-126): 2.38e-25: 96.3: 52.59
+	Mm
		718971 CDK4_MOUSE (1-303): 3.21e-128: 368: 100.00		CDN2B_MOUSE (12-126): 7.65e-26: 97.1: 52.59
+	Hs
		549084 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		CDN2B_HUMAN (12-126): 2.38e-25: 96.3: 52.59
+	Hs
		842727 CDK6_HUMAN (5-299): 4.48e-128: 369: 68.58		CDN2A_HUMAN (9-126): 2.71e-23: 91.3: 51.26
+	Hs
		549083 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		CDN2A_HUMAN (9-126): 2.71e-23: 91.3: 51.26
+	Mm
		718969 CDK4_MOUSE (1-303): 3.21e-128: 368: 100.00		CDN2A_MOUSE (18-126): 3.05e-21: 86.7: 49.09
+	Hs
		1025481 CDK5_HUMAN (3-301): 6.07e-125: 360: 43.75		MIB1_HUMAN (11-114): 7.51e-16: 75.6: 20.55
+	Hs
		549199 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		ANR52_HUMAN (12-158): 1.88e-12: 65.9: 36.67