HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: PHLP2 (Q6ZVD8)
PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)
Gene: PHLPP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.798

Property	Details
Experiments	24670654, 17386267
Identification Methods	anti tag coimmunoprecipitation, phosphatase assay
Interaction Type	physical association, dephosphorylation reaction, association

Property	Details
Interacting Pfam domains	LRR_6~Pkinase, LRR_8~Pkinase, PP2C~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005929 - cilium GO:0035556 - intracellular signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 1323
+	Rn
		93209 AKT1_RAT (1-480): 0: 590: 98.13		D4A254_RAT (1-1323): 0: 959: 92.60
+	Hs
		728602 AKT2_HUMAN (1-477): 0: 562: 81.21		PHLP2_HUMAN (1-1323): 0: 978: 100.00
+	Hs
		1256839 AKT3_HUMAN (1-478): 0: 558: 82.50		PHLP2_HUMAN (1-1323): 0: 978: 100.00
+	Hs
		247238 AKT1_HUMAN (1-480): 0: 589: 100.00		PHLP1_HUMAN (37-1300): 0: 837: 52.92
+	Hs
		436690 KPCB_HUMAN (14-479): 1.32e-148: 441: 35.46		PHLP2_HUMAN (1-1323): 0: 978: 100.00
+	Hs
		658610 KS6B1_HUMAN (92-479): 1.41e-148: 436: 39.54		PHLP2_HUMAN (1-1323): 0: 978: 100.00
+	Hs
		247239 AKT2_HUMAN (1-477): 0: 562: 81.21		PHLP1_HUMAN (37-1300): 0: 837: 52.92
+	Hs
		247467 AKT3_HUMAN (1-478): 0: 558: 82.50		PHLP1_HUMAN (37-1300): 0: 837: 52.92
+	Hs
		247209 KPCB_HUMAN (14-479): 1.32e-148: 441: 35.46		PHLP1_HUMAN (37-1300): 0: 837: 52.92
+	Hs
		247229 KS6B1_HUMAN (92-479): 1.41e-148: 436: 39.54		PHLP1_HUMAN (37-1300): 0: 837: 52.92
+	Hs
		603268 KPCA_HUMAN (14-479): 2.01e-148: 440: 36.11		SCRIB_HUMAN (438-732): 2.2e-12: 74.3: 29.00
+	Hs
		908111 KS6A3_HUMAN (36-455): 4.73e-103: 325: 23.01		SCRIB_HUMAN (438-732): 2.2e-12: 74.3: 29.00
+	Hs
		835737 KPCI_HUMAN (139-474): 7.49e-101: 316: 45.53		ERBIN_HUMAN (461-746): 7.32e-10: 65.9: 24.75
+	Hs
		1122234 KS6A2_HUMAN (85-452): 9.72e-94: 301: 25.39		SCRIB_HUMAN (438-732): 2.2e-12: 74.3: 29.00
+	Hs
		1122237 KS6A1_HUMAN (85-407): 1.02e-91: 296: 26.39		SCRIB_HUMAN (438-732): 2.2e-12: 74.3: 29.00
+	Hs
		1148382 KS6A1_HUMAN (85-407): 1.02e-91: 296: 26.39		ERBIN_HUMAN (461-746): 7.32e-10: 65.9: 24.75