HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: PI3R4 (Q99570)
Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)
Gene: PIK3R4

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	15324660, 17353931, unassigned3799
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 1358
+	Hs
		971923 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		PI3R4_HUMAN (1-1358): 0: 1156: 100.00
+	Hs
		971985 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		SIK2_HUMAN (10-996): 1.44e-151: 484: 12.43
+	Hs
		730227 1433B_HUMAN (1-246): 3.49e-144: 404: 100.00		SIK2_HUMAN (10-996): 1.44e-151: 484: 12.43
+	At
		1030913 14332_ARATH (1-241): 4.77e-145: 407: 63.27		CIPKC_ARATH (1-491): 1.39e-113: 367: 15.32
+	At
		1379653 14337_ARATH (1-239): 1.26e-144: 406: 61.73		CIPKC_ARATH (1-491): 1.39e-113: 367: 15.32
+	At
		840534 14333_ARATH (3-241): 4.46e-143: 402: 62.96		CIPKC_ARATH (1-491): 1.39e-113: 367: 15.32
+	Mm
		704208 1433Z_MOUSE (3-244): 3.15e-142: 399: 88.02		KCC2B_MOUSE (24-470): 6.28e-103: 340: 15.13
+	Hs
		971494 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		KCC2D_HUMAN (24-470): 9.14e-101: 332: 14.91
+	Mm
		989991 1433Z_MOUSE (3-244): 3.15e-142: 399: 88.02		KCC2D_MOUSE (24-470): 9.14e-101: 332: 14.91
+	Hs
		972147 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		KCC2A_HUMAN (24-470): 2.27e-98: 325: 15.35
+	Hs
		730365 1433B_HUMAN (1-246): 3.49e-144: 404: 100.00		KCC2A_HUMAN (24-470): 2.27e-98: 325: 15.35
+	Mm
		548939 1433Z_MOUSE (3-244): 3.15e-142: 399: 88.02		KCC2A_MOUSE (24-470): 3.75e-98: 324: 15.35
+	At
		1030853 14332_ARATH (1-241): 4.77e-145: 407: 63.27		PRL2_ARATH (811-1289): 1.53e-83: 284: 15.46
+	Mm
		972241 1433E_MOUSE (3-243): 4.41e-144: 405: 65.43		NUAK1_MOUSE (2-311): 1.94e-75: 266: 21.56
+	Hs
		244241 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		NUAK1_HUMAN (6-311): 7.63e-74: 262: 21.20
+	Hs
		244229 1433B_HUMAN (1-246): 3.49e-144: 404: 100.00		NUAK1_HUMAN (6-311): 7.63e-74: 262: 21.20
+	Hs
		971981 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		NUAK2_HUMAN (7-311): 1.51e-67: 242: 18.91
+	Hs
		943639 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		SIK1_HUMAN (26-333): 4.98e-60: 224: 17.98
+	Hs
		729710 1433B_HUMAN (1-246): 3.49e-144: 404: 100.00		SIK1_HUMAN (26-333): 4.98e-60: 224: 17.98
+	At
		840402 14333_ARATH (3-241): 4.46e-143: 402: 62.96		PRL1_ARATH (761-1189): 1.23e-13: 77.2: 12.47