Protein: PI3R4
Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)

Gene: PI3R4, PIK3R4
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q99570

Gene Ontology (top 5):
GO:0000425 - pexophagy
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005770 - late endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1126749

BECN1
Beclin-1

17

3

Small-scale

0.987

High

1252948

BAKOR
Beclin 1-associated autophagy-related key regulator

17

1

Small-scale

0.985

High

1337311

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

12

8

Small-scale

0.978

High

1405338

UVRAG
UV radiation resistance-associated gene protein

5

1

Small-scale

0.919

High

992924

RACK1
Small ribosomal subunit protein RACK1

2

11

Small-scale

0.834

High

1007220

TCPB
T-complex protein 1 subunit beta

2

16

High-throughput

0.811

High

1198274

FND3B
Fibronectin type III domain-containing protein 3B

2

5

High-throughput

0.783

High

1390256

NRBF2
Nuclear receptor-binding factor 2

10

2

Small-scale

0.758

High

159819

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

20

Small-scale

0.754

High

182745

GP182
G-protein coupled receptor 182

1

4

High-throughput

0.691

High

610844

TCPA
T-complex protein 1 subunit alpha

1

12

High-throughput

0.691

High

679241

DNJB1
DnaJ homolog subfamily B member 1

1

5

High-throughput

0.691

High

783649

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

19

High-throughput

0.691

High

821524

TCPZ
T-complex protein 1 subunit zeta

1

13

High-throughput

0.691

High

876136

TCPE
T-complex protein 1 subunit epsilon

1

15

High-throughput

0.691

High

882109

TCPG
T-complex protein 1 subunit gamma

1

15

High-throughput

0.691

High

899192

TCPQ
T-complex protein 1 subunit theta

1

19

High-throughput

0.691

High

899543

TCPD
T-complex protein 1 subunit delta

1

11

High-throughput

0.691

High

984510

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.691

High

1093297

FLII
Protein flightless-1 homolog

1

6

High-throughput

0.691

High

1405326

TCPH
T-complex protein 1 subunit eta

1

15

High-throughput

0.691

High

1405328

DNAI2
Dynein axonemal intermediate chain 2

1

9

High-throughput

0.691

High

1405333

PAR6A
Partitioning defective 6 homolog alpha

1

11

High-throughput

0.691

High

1365936

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

4

1

Small-scale

0.683

High

1405341

HECD1
E3 ubiquitin-protein ligase HECTD1

2

14

High-throughput

0.675

High

1361899

TITIN
Titin

1

6

High-throughput

0.665

High

730185

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.643

High

971923

1433E
14-3-3 protein epsilon

3

15

Small-scale

0.633

High

1405332

PACER
Protein associated with UVRAG as autophagy enhancer

2

1

High-throughput

0.628

High

771215

APJ
Apelin receptor

1

3

High-throughput

0.618

High

1101639

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

4

High-throughput

0.618

High

1111218

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.618

High

1291873

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

3

High-throughput

0.618

High

1405343

GPR55
G-protein coupled receptor 55

1

6

High-throughput

0.618

High

242693

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.618

High

363758

EGFR
Epidermal growth factor receptor

1

5

Small-scale

0.618

High

412494

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.618

High

631430

RAB5A
Ras-related protein Rab-5A

1

10

High-throughput

0.618

High

839346

MTOR
Serine/threonine-protein kinase mTOR

1

15

Small-scale

0.618

High

856880

BAG6
Large proline-rich protein BAG6

1

8

High-throughput

0.618

High

901517

RAB7A
Ras-related protein Rab-7a

1

10

High-throughput

0.618

High

902027

RAB9A
Ras-related protein Rab-9A

1

8

High-throughput

0.618

High

907552

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

Small-scale

0.618

High

1235318

STYK1
Tyrosine-protein kinase STYK1

1

6

Small-scale

0.618

High

1371633

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

High-throughput

0.618

High

1405329

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.618

High

208887

ZBT24
Zinc finger and BTB domain-containing protein 24

1

4

High-throughput

0.595

High

332768

EPM2A
Laforin

1

0

Small-scale

0.586

High

966789

1433G
14-3-3 protein gamma

2

20

High-throughput

0.584

High

1405339

ZRAN1
Ubiquitin thioesterase ZRANB1

2

7

High-throughput

0.584

High

638509

FPR1
fMet-Leu-Phe receptor

1

4

High-throughput

0.575

High

669355

ACKR3
Atypical chemokine receptor 3

1

3

High-throughput

0.575

High

944044

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.575

High

1367101

ESR2
Estrogen receptor beta

2

11

High-throughput

0.571

High

1162013

H31T
Histone H3.1t

1

12

High-throughput

0.553

High

1255211

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

1405330

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.553

High

220005

XRCC3
DNA repair protein XRCC3

1

2

High-throughput

0.536

High

457638

TBB5
Tubulin beta chain

1

2

High-throughput

0.536

High

538667

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

7

High-throughput

0.536

High

612748

RL7
Large ribosomal subunit protein uL30

1

3

High-throughput

0.536

High

688118

EF1G
Elongation factor 1-gamma

1

5

High-throughput

0.536

High

731558

STIP1
Stress-induced-phosphoprotein 1

1

12

High-throughput

0.536

High

867367

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

1382371

SPSB4
SPRY domain-containing SOCS box protein 4

1

13

High-throughput

0.536

High

1405340

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.536

High

1405337

RRBP1
Ribosome-binding protein 1

1

12

High-throughput

0.515

High

1219538

ANR22
Ankyrin repeat domain-containing protein 22

1

5

High-throughput

0.514

High

1366195

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.514

High

342021

CEP43
Centrosomal protein 43

1

0

High-throughput

0.513

High

445673

KCRM
Creatine kinase M-type

1

0

High-throughput

0.513

High

963360

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.513

High

1404642

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

1405335

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.513

High

1405344

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

1198509

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.493

High

472202

TRFM
Melanotransferrin

1

1

High-throughput

0.489

High

1323920

KLH34
Kelch-like protein 34

1

2

High-throughput

0.489

High

173264

XPO1
Exportin-1

1

15

High-throughput

0.479

High

346232

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

9

High-throughput

0.479

High

487669

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.479

High

562345

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.479

High

604171

CXA1
Gap junction alpha-1 protein

1

2

Small-scale

0.479

High

681705

PSA4
Proteasome subunit alpha type-4

1

4

High-throughput

0.479

High

1049705

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1161048

FSCN1
Fascin

1

1

High-throughput

0.479

High

1338333

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

1397341

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1405327

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

6

High-throughput

0.479

High

1405331

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1405342

MARE3
Microtubule-associated protein RP/EB family member 3

1

1

High-throughput

0.479

High

560492

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.458

High

1405336

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

139137

KRIT1
Krev interaction trapped protein 1

1

4

Small-scale

0.437

High

218671

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.437

High

372940

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.437

High

768979

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

271564

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.426

High

1258557

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

5

High-throughput

0.407

High

1335686

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.407

High

1405334

JADE2
E3 ubiquitin-protein ligase Jade-2

3

0

High-throughput

0.347

High

261860

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.279

Low

1350868

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1233439

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

947040

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025