HitPredict

Interactor 1: B3KSH4 (B3KSH4)
Huntingtin interacting protein 2, isoform CRA_a (cDNA FLJ36214 fis, clone THYMU2000672, highly similar to Ubiquitin-conjugating enzyme E2-25 kDa)
Gene: HIP2

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.80	0.528

Property	Details
Experiments	19549727
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 97 Hs			1 336
+	Hs
		957653 UBE2K_HUMAN (1-97): 6.08e-34: 117: 100.00		RING2_HUMAN (1-336): 2.01e-112: 331: 100.00
+	Hs
		957595 UBE2K_HUMAN (1-97): 6.08e-34: 117: 100.00		RING1_HUMAN (6-336): 3.66e-69: 223: 51.24
+	Hs
		75509 B3KSH4_HUMAN (1-97): 3.95e-34: 114: 100.00		RING1_HUMAN (6-336): 3.66e-69: 223: 51.24
+	Hs
		957675 UBE2K_HUMAN (1-97): 6.08e-34: 117: 100.00		TRI39_HUMAN (42-309): 4.47e-48: 171: 16.67
+	Hs
		75539 B3KSH4_HUMAN (1-97): 3.95e-34: 114: 100.00		TRI39_HUMAN (42-309): 4.47e-48: 171: 16.67
+	Hs
		957641 UBE2K_HUMAN (1-97): 6.08e-34: 117: 100.00		TRI43_HUMAN (45-303): 9.27e-48: 168: 13.11
+	Hs
		75520 B3KSH4_HUMAN (1-97): 3.95e-34: 114: 100.00		TRI43_HUMAN (45-303): 9.27e-48: 168: 13.11
+	Hs
		957663 UBE2K_HUMAN (1-97): 6.08e-34: 117: 100.00		TRIM6_HUMAN (42-281): 9.86e-43: 156: 15.32
+	Hs
		957655 UBE2K_HUMAN (1-97): 6.08e-34: 117: 100.00		BARD1_HUMAN (1-291): 6.46e-39: 148: 12.42
+	Hs
		571916 UBE2K_HUMAN (1-97): 6.08e-34: 117: 100.00		TRI27_HUMAN (36-282): 2.23e-37: 141: 16.08
+	Hs
		957664 UBE2K_HUMAN (1-97): 6.08e-34: 117: 100.00		TRIM5_HUMAN (38-285): 7.02e-37: 140: 14.23
+	Hs
		75506 B3KSH4_HUMAN (1-97): 3.95e-34: 114: 100.00		TRI27_HUMAN (36-282): 2.23e-37: 141: 16.08
+	Hs
		75532 B3KSH4_HUMAN (1-97): 3.95e-34: 114: 100.00		TRIM5_HUMAN (38-285): 7.02e-37: 140: 14.23
+	Zm
		13558 B4FC97_MAIZE (1-52): 4.52e-31: 108: 38.46		A0A1D6FSN7_MAIZE (26-220): 1.01e-37: 142: 27.18
+	Hs
		798918 UBE2K_HUMAN (1-97): 6.08e-34: 117: 100.00		BRCA1_HUMAN (36-214): 1.16e-33: 133: 25.79
+	Hs
		571922 UB2D2_HUMAN (1-51): 8.37e-31: 107: 39.22		TRI27_HUMAN (36-282): 2.23e-37: 141: 16.08
+	Mm
		982385 UB2D2_MOUSE (1-51): 8.37e-31: 107: 39.22		TRI17_MOUSE (36-289): 4.97e-35: 134: 17.54
+	Hs
		587380 UB2D2_HUMAN (1-51): 8.37e-31: 107: 39.22		RAG1_HUMAN (42-197): 1.73e-29: 121: 20.51
+	Hs
		957637 UBE2K_HUMAN (1-97): 6.08e-34: 117: 100.00		RN138_HUMAN (34-201): 1.76e-27: 109: 17.06
+	Hs
		75519 B3KSH4_HUMAN (1-97): 3.95e-34: 114: 100.00		RN138_HUMAN (34-201): 1.76e-27: 109: 17.06