HitPredict

Interactor 1: LRP2 (P98164)
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Gene: LRP2

Interactor 2: SOST (Q9BQB4)
Sclerostin
Gene: SOST

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ldl_recept_b~Sclerostin
Common GO terms	GO:0005794 - Golgi apparatus GO:0030514 - negative regulation of BMP signaling pathway
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 4655 Hs			1 213
+	Hs
		1269017 SORL_HUMAN (166-470): 5.79e-19: 98: 16.82		SOST_HUMAN (1-213): 2.91e-135: 379: 100.00
+	Hs
		254290 LRP4_HUMAN (3839-4093): 6.21e-15: 84.9: 22.90		SOST_HUMAN (1-213): 2.91e-135: 379: 100.00
+	Hs
		270322 LRP6_HUMAN (3113-3241): 3.94e-09: 65.6: 16.30		SOST_HUMAN (1-213): 2.91e-135: 379: 100.00
+	Hs
		258340 LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42		SOST_HUMAN (1-213): 2.91e-135: 379: 100.00
+	Mm
		1265073 LRP5_MOUSE (3113-3254): 3.06e-09: 66: 17.57		SOST_MOUSE (1-213): 8.98e-132: 370: 87.32
+	Mm
		291932 LRP6_MOUSE (3113-3241): 3.77e-09: 65.6: 16.30		SOST_MOUSE (1-213): 8.98e-132: 370: 87.32