HitPredict

Interactor 1: PTN12 (P35831)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (MPTP-PEST) (Protein-tyrosine phosphatase P19) (P19-PTP)
Gene: Ptpn12

Interactor 2: EGFR (Q01279)
Epidermal growth factor receptor (EC 2.7.10.1)
Gene: EGFR

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12614164
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 775 Mm			1 1210
+	Hs
		363164 PTN12_HUMAN (1-775): 0: 748: 83.74		EGFR_HUMAN (1-1210): 0: 1228: 90.35
+	Hs
		1050795 PTN12_HUMAN (1-775): 0: 748: 83.74		ERBB4_HUMAN (7-1198): 0: 1155: 50.66
+	Hs
		410791 PTN12_HUMAN (1-775): 0: 748: 83.74		ERBB2_HUMAN (7-1203): 0: 1110: 48.34
+	Hs
		641576 PTN12_HUMAN (1-775): 0: 748: 83.74		ERBB3_HUMAN (1-1164): 0: 1065: 42.15
+	Hs
		364063 PTN22_HUMAN (1-774): 0: 541: 33.03		EGFR_HUMAN (1-1210): 0: 1228: 90.35
+	Hs
		362628 PTPRC_HUMAN (1-637): 8.54e-139: 443: 20.58		EGFR_HUMAN (1-1210): 0: 1228: 90.35
+	Hs
		363775 PTN18_HUMAN (2-405): 3.45e-145: 435: 34.44		EGFR_HUMAN (1-1210): 0: 1228: 90.35
+	Hs
		411128 PTN22_HUMAN (1-774): 0: 541: 33.03		ERBB2_HUMAN (7-1203): 0: 1110: 48.34
+	Hs
		410537 PTPRC_HUMAN (1-637): 8.54e-139: 443: 20.58		ERBB2_HUMAN (7-1203): 0: 1110: 48.34
+	Hs
		411020 PTN18_HUMAN (2-405): 3.45e-145: 435: 34.44		ERBB2_HUMAN (7-1203): 0: 1110: 48.34
+	Hs
		1050783 PTN12_HUMAN (1-775): 0: 748: 83.74		ACK1_HUMAN (693-969): 4.97e-55: 211: 39.58
+	Hs
		1050782 PTN12_HUMAN (1-775): 0: 748: 83.74		FAK1_HUMAN (718-993): 6.29e-54: 207: 38.04
+	Hs
		1050790 PTN12_HUMAN (1-775): 0: 748: 83.74		FAK2_HUMAN (718-976): 7.46e-53: 204: 38.40
+	Hs
		465494 PTN12_HUMAN (1-775): 0: 748: 83.74		IGF1R_HUMAN (356-641): 5.06e-21: 102: 23.73
+	Hs
		439707 PTN12_HUMAN (1-775): 0: 748: 83.74		INSR_HUMAN (354-658): 5.7e-17: 89.1: 20.68
+	Hs
		849087 PTN22_HUMAN (1-774): 0: 541: 33.03		ZAP70_HUMAN (720-963): 1.45e-52: 197: 39.18
+	Hs
		471740 PTPRC_HUMAN (1-637): 8.54e-139: 443: 20.58		ACK1_HUMAN (693-969): 4.97e-55: 211: 39.58
+	Hs
		840981 PTN18_HUMAN (2-405): 3.45e-145: 435: 34.44		ABL2_HUMAN (709-976): 1.96e-52: 203: 40.74
+	Dm
		409156 PTP10_DROME (4-414): 1.67e-134: 441: 26.38		EGFR_DROME (31-364): 3.98e-25: 115: 21.65
+	Hs
		439622 PTPRC_HUMAN (1-637): 8.54e-139: 443: 20.58		INSR_HUMAN (354-658): 5.7e-17: 89.1: 20.68