Protein: PTN22
Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)

Gene: PTN22, PTPN22
Organism: Homo sapiens
Interactions: 66
UniProt ID: Q9Y2R2

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0004726 - non-membrane spanning protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

364063

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.867

High

440254

LCK
Tyrosine-protein kinase Lck

3

20

Small-scale

0.866

High

1490877

PTN22
Tyrosine-protein phosphatase non-receptor type 22

3

17

Small-scale

0.834

High

849087

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

Small-scale

0.765

High

834241

CSK
Tyrosine-protein kinase CSK

2

20

High-throughput

0.754

High

988051

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.747

High

584601

VAV
Proto-oncogene vav

1

18

Small-scale

0.691

High

220821

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

2

14

Small-scale

0.652

High

557543

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.647

High

855816

CRK
Adapter molecule crk

1

20

High-throughput

0.647

High

1436776

PPIP2
Proline-serine-threonine phosphatase-interacting protein 2

2

12

High-throughput

0.601

High

286791

SKAP2
Src kinase-associated phosphoprotein 2

1

20

Small-scale

0.586

High

635919

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

2

Small-scale

0.586

High

411128

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.575

High

412847

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.575

High

484246

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.575

High

533862

GHR
Growth hormone receptor

1

20

High-throughput

0.575

High

460289

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

1

Small-scale

0.536

High

935322

TERA
Transitional endoplasmic reticulum ATPase

1

6

Small-scale

0.536

High

475077

VIME
Vimentin

1

2

High-throughput

0.515

High

651468

CBL
E3 ubiquitin-protein ligase CBL

1

15

Small-scale

0.515

High

725569

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

2

High-throughput

0.515

High

889527

CLK1
Dual specificity protein kinase CLK1

1

2

High-throughput

0.501

High

1006804

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.501

High

1051983

KPCD
Protein kinase C delta type

1

2

Small-scale

0.501

High

1154200

ITSN1
Intersectin-1

1

7

High-throughput

0.501

High

456068

CRGD
Gamma-crystallin D

1

0

High-throughput

0.493

High

386498

SPTA1
Spectrin alpha chain, erythrocytic 1

1

1

Small-scale

0.479

High

415950

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.479

High

568868

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

2

High-throughput

0.479

High

698071

CALR
Calreticulin

1

11

High-throughput

0.479

High

996562

ACTS
Actin, alpha skeletal muscle

1

5

Small-scale

0.479

High

1095011

TRAF3
TNF receptor-associated factor 3

1

9

Small-scale

0.479

High

1136763

MD2BP
MAD2L1-binding protein

1

1

High-throughput

0.479

High

1178659

KIF7
Kinesin-like protein KIF7

1

2

High-throughput

0.479

High

1292984

AROS
Active regulator of SIRT1

1

1

High-throughput

0.479

High

1295602

MIB1
E3 ubiquitin-protein ligase MIB1

1

4

High-throughput

0.479

High

1338446

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1411392

LZTS2
Leucine zipper putative tumor suppressor 2

1

5

High-throughput

0.479

High

1411435

CAB45
45 kDa calcium-binding protein

1

6

High-throughput

0.479

High

1462493

CP131
Centrosomal protein of 131 kDa

1

1

High-throughput

0.479

High

217297

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.458

High

359767

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.458

High

887356

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.458

High

949468

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.458

High

1163566

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.458

High

1178037

MOONR
Protein moonraker

1

0

High-throughput

0.458

High

1361187

PIBF1
Progesterone-induced-blocking factor 1

1

0

High-throughput

0.458

High

1438545

TPC
Mitochondrial thiamine pyrophosphate carrier

1

0

High-throughput

0.458

High

1446559

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

1461239

ACAD8
Isobutyryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

1490686

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.458

High

193643

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

8

High-throughput

0.445

High

618297

CADH2
Cadherin-2

1

20

High-throughput

0.445

High

842673

WASP
Actin nucleation-promoting factor WAS

1

11

High-throughput

0.445

High

1227743

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.445

High

124539

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.437

High

229852

CALU
Calumenin

1

6

High-throughput

0.437

High

1145721

RCN1
Reticulocalbin-1

1

6

High-throughput

0.437

High

1359206

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

2

High-throughput

0.437

High

1387732

TBC31
TBC1 domain family member 31

1

1

High-throughput

0.437

High

228875

SCO2
Protein SCO2 homolog, mitochondrial

1

0

High-throughput

0.249

Low

354002

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

High-throughput

0.249

Low

1242330

SFXN4
Sideroflexin-4

1

0

High-throughput

0.249

Low

1397854

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025