Interactor 1: ZAP70 (P43403)
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
Gene: ZAP70
Interactor 2: PTN22 (Q9Y2R2)
Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)
Gene: PTPN22
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.58 | 1.00 | 0.765 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 16461343 |
| Identification Methods | affinity chromatography technology, pull down, phosphatase assay |
| Interaction Type | physical association, association, direct interaction, dephosphorylation reaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030217 - T cell differentiation GO:0050852 - T cell receptor signaling pathway |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
