HitPredict

Interactor 1: STA5A (P42229)
Signal transducer and activator of transcription 5A
Gene: STAT5A

Interactor 2: JAK3 (P52333)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Gene: JAK3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.57 1.00 0.757

The method score is based on:

Property Details
Experiments 9047382, 18250158
Identification Methods two hybrid, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0005829 - cytosol
GO:0007259 - cell surface receptor signaling pathway via JAK-STAT
GO:0019221 - cytokine-mediated signaling pathway
GO:0035723 - interleukin-15-mediated signaling pathway
GO:0035771 - interleukin-4-mediated signaling pathway
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 794
Hs

1 1124
+ Hs
+ Rn
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024