HitPredict

Interactor 1: ACV1B (P36896)
Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
Gene: ACVR1B

Interactor 2: SMAD4 (Q13485)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
Gene: SMAD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.38 0.60 0.479

The method score is based on:

Property Details
Experiments 35512704
Identification Methods pull down
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001701 - in utero embryonic development
GO:0006355 - regulation of DNA-templated transcription
GO:0010628 - positive regulation of gene expression
GO:0030308 - negative regulation of cell growth
GO:0032924 - activin receptor signaling pathway
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 505
Hs

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Service provided by Combinatics, Japan

Last updated: 11Aug2025