HitPredict

Interactor 1: BIRC5 (O15392)
Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)
Gene: BIRC5

Interactor 2: CASP3 (P42574)
Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
Gene: CASP3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	9850056, 11170436, 16540654
Identification Methods	pull down, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BIR~Peptidase_C14
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process and 1 others more... GO:0007605 - sensory perception of sound
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 142 Hs			1 277
+	Hs
		788230 BIRC6_HUMAN (8-88): 8.14e-36: 132: 37.04		CASP3_HUMAN (1-277): 2.23e-146: 412: 100.00
+	Hs
		788221 BIRC7_HUMAN (7-104): 1.33e-33: 121: 29.59		CASP3_HUMAN (1-277): 2.23e-146: 412: 100.00
+	Hs
		177663 BIRC5_HUMAN (1-142): 2.27e-60: 184: 100.00		CASP7_HUMAN (2-275): 1.78e-114: 333: 50.35
+	Hs
		788193 BIRC3_HUMAN (3-96): 8.83e-22: 91.7: 27.66		CASP3_HUMAN (1-277): 2.23e-146: 412: 100.00
+	Hs
		177664 BIRC5_HUMAN (1-142): 2.27e-60: 184: 100.00		CASP9_HUMAN (34-275): 1.58e-95: 288: 33.21
+	Hs
		876964 BIRC6_HUMAN (8-88): 8.14e-36: 132: 37.04		CASP7_HUMAN (2-275): 1.78e-114: 333: 50.35
+	Hs
		876960 BIRC7_HUMAN (7-104): 1.33e-33: 121: 29.59		CASP7_HUMAN (2-275): 1.78e-114: 333: 50.35
+	Hs
		876944 BIRC3_HUMAN (3-96): 8.83e-22: 91.7: 27.66		CASP7_HUMAN (2-275): 1.78e-114: 333: 50.35
+	Hs
		877004 BIRC6_HUMAN (8-88): 8.14e-36: 132: 37.04		CASP9_HUMAN (34-275): 1.58e-95: 288: 33.21
+	Hs
		1059377 BIRC6_HUMAN (8-88): 8.14e-36: 132: 37.04		CASP8_HUMAN (25-275): 8.12e-93: 283: 35.32
+	Hs
		876987 Q6PIA0_HUMAN (12-122): 1.73e-36: 126: 26.13		CASP9_HUMAN (34-275): 1.58e-95: 288: 33.21
+	Hs
		876998 BIRC8_HUMAN (12-122): 3.28e-36: 126: 26.13		CASP9_HUMAN (34-275): 1.58e-95: 288: 33.21
+	Hs
		876997 BIRC7_HUMAN (7-104): 1.33e-33: 121: 29.59		CASP9_HUMAN (34-275): 1.58e-95: 288: 33.21
+	Dm
		136289 DIAP1_DROME (8-89): 7.6e-22: 91.3: 26.83		DRICE_DROME (36-275): 1.57e-101: 301: 41.94
+	Dm
		137119 DIAP1_DROME (8-89): 7.6e-22: 91.3: 26.83		CASP1_DROME (35-275): 1.11e-100: 298: 39.02
+	Hs
		876980 BIRC3_HUMAN (3-96): 8.83e-22: 91.7: 27.66		CASP9_HUMAN (34-275): 1.58e-95: 288: 33.21
+	Hs
		1035745 BIRC3_HUMAN (3-96): 8.83e-22: 91.7: 27.66		CASP8_HUMAN (25-275): 8.12e-93: 283: 35.32
+	Hs
		667461 BIRC3_HUMAN (3-96): 8.83e-22: 91.7: 27.66		CASP1_HUMAN (2-276): 3.37e-78: 244: 26.26
+	Hs
		1035946 BIRC3_HUMAN (3-96): 8.83e-22: 91.7: 27.66		CASPA_HUMAN (36-230): 2.98e-72: 232: 34.65
+	Hs
		181612 BIRC3_HUMAN (3-96): 8.83e-22: 91.7: 27.66		CFLAR_HUMAN (19-240): 4.13e-58: 194: 27.20