HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: EIF3B (P55884)
Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116)
Gene: EIF3B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	18423201, 16286006, 21045808
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2549 Hs			1 814
+	Hs
		787437 MTOR_HUMAN (1-2549): 0: 2102: 100.00		WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71
+	Hs
		903639 TRRAP_HUMAN (925-2548): 0: 720: 15.53		WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71
+	Hs
		903121 PRKDC_HUMAN (695-2548): 0: 686: 14.83		WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71
+	Hs
		1074814 TRRAP_HUMAN (925-2548): 0: 720: 15.53		TAF5_HUMAN (304-497): 3.2e-13: 75.6: 18.32
+	Hs
		267807 TRRAP_HUMAN (925-2548): 0: 720: 15.53		TAF5L_HUMAN (343-501): 2.2e-12: 72.5: 19.63
+	Sc
		744612 TRA1_YEAST (202-2549): 0: 657: 12.49		TAF5_YEAST (304-498): 7.47e-13: 74.5: 19.61
+	Hs
		903400 GCN1_HUMAN (245-1372): 1.05e-38: 162: 12.17		WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71