HitPredict

Interactor 1: IQGA1 (P46940)
Ras GTPase-activating-like protein IQGAP1 (p195)
Gene: IQGAP1

Interactor 2: MYL6 (P60660)
Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6)
Gene: MYL6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.736

Property	Details
Experiments	28514442, 33961781, 35271311, 26496610, 27684187, 37071682
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1657 Hs			1 151
+	Hs
		521679 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		MYL4_HUMAN (3-151): 7.24e-58: 180: 77.48
+	Hs
		409454 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		MYL1_HUMAN (3-150): 1.84e-56: 176: 74.32
+	Hs
		441667 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		MYL3_HUMAN (3-150): 2.39e-55: 173: 73.33
+	Hs
		538647 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76
+	Hs
		483913 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		CALM1_HUMAN (5-77): 1.13e-11: 60.6: 28.77
+	Hs
		483984 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		CALM2_HUMAN (5-77): 1.13e-11: 60.6: 28.77
+	Hs
		484079 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		CALM3_HUMAN (5-77): 1.13e-11: 60.6: 28.77
+	Hs
		648473 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		CALL3_HUMAN (5-77): 1.25e-10: 57.9: 26.03
+	Hs
		521684 IQGA3_HUMAN (13-1657): 0: 1561: 58.87		MYL4_HUMAN (3-151): 7.24e-58: 180: 77.48
+	Hs
		538684 IQGA3_HUMAN (13-1657): 0: 1561: 58.87		MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76
+	Hs
		891555 IQGA3_HUMAN (13-1657): 0: 1561: 58.87		MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00
+	Hs
		57913 A2RRC9_HUMAN (13-1657): 0: 1566: 58.93		B4DJ51_HUMAN (5-77): 1.13e-11: 60.6: 28.77
+	Hs
		483946 IQGA3_HUMAN (13-1657): 0: 1561: 58.87		CALM1_HUMAN (5-77): 1.13e-11: 60.6: 28.77
+	Hs
		484020 IQGA3_HUMAN (13-1657): 0: 1561: 58.87		CALM2_HUMAN (5-77): 1.13e-11: 60.6: 28.77
+	Hs
		484161 IQGA3_HUMAN (13-1657): 0: 1561: 58.87		CALM3_HUMAN (5-77): 1.13e-11: 60.6: 28.77
+	Hs
		891518 IQGA2_HUMAN (254-1657): 0: 1321: 54.09		MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00
+	Hs
		648499 IQGA2_HUMAN (254-1657): 0: 1321: 54.09		CALL3_HUMAN (5-77): 1.25e-10: 57.9: 26.03
+	Hs
		891587 SYGP1_HUMAN (635-1477): 1.49e-108: 380: 12.26		MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00
+	Hs
		483957 SYGP1_HUMAN (635-1477): 1.49e-108: 380: 12.26		CALM1_HUMAN (5-77): 1.13e-11: 60.6: 28.77
+	Sp
		144978 IQG1_SCHPO (11-204): 6.98e-41: 167: 38.14		CALM_SCHPO (5-77): 4.59e-11: 59: 26.03