Protein: END3
Actin cytoskeleton-regulatory complex protein END3 (Endocytosis protein 3)

Gene: END3
Organism: Saccharomyces cerevisiae S288C
Interactions: 138
UniProt ID: P39013

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0006897 - endocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

739071

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

12

14

Small-scale

0.762

High

744847

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

5

8

Small-scale

0.724

High

809247

LAS17
Proline-rich protein LAS17

4

10

High-throughput

0.700

High

751851

SLA2
Protein SLA2

3

7

Small-scale

0.661

High

809210

AP18B
Clathrin coat assembly protein AP180B

3

12

Small-scale

0.639

High

760551

SCD5
Protein SCD5

2

1

Small-scale

0.619

High

778983

MYO3
Myosin-3

2

3

High-throughput

0.614

High

790575

VRP1
Verprolin

2

4

High-throughput

0.614

High

806023

KEL1
Kelch repeat-containing protein 1

2

1

High-throughput

0.595

High

809188

RAD26
DNA repair and recombination protein RAD26

2

1

High-throughput

0.595

High

644778

CLH
Clathrin heavy chain

2

8

Small-scale

0.595

High

809231

ENT2
Epsin-2

2

20

Small-scale

0.595

High

809248

ENT1
Epsin-1

2

20

Small-scale

0.595

High

753079

NIP80
Protein NIP100

2

17

High-throughput

0.594

High

795345

ATG8
Autophagy-related protein 8

2

3

Small-scale

0.584

High

809225

SPC19
DASH complex subunit SPC19

2

0

High-throughput

0.570

High

745002

YSC84
Protein YSC84

1

19

High-throughput

0.560

High

809187

SSB2
Ribosome-associated molecular chaperone SSB2

2

9

High-throughput

0.552

High

736096

ARP2
Actin-related protein 2

2

5

Small-scale

0.543

High

805390

BZZ1
Protein BZZ1

1

20

High-throughput

0.541

High

809191

PRK1
Actin-regulating kinase PRK1

1

11

High-throughput

0.536

High

809218

ARK1
Actin-regulating kinase 1

1

11

High-throughput

0.536

High

809220

NUM1
Nuclear migration protein NUM1

2

7

High-throughput

0.535

High

747723

SMC1
Structural maintenance of chromosomes protein 1

2

3

High-throughput

0.526

High

750660

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.515

High

609223

CLC1
Clathrin light chain

1

9

Small-scale

0.501

High

809194

GTS1
Protein GTS1

1

4

Small-scale

0.501

High

751044

XRS2
DNA repair protein XRS2

1

0

High-throughput

0.493

High

780955

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.493

High

430850

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

1

Small-scale

0.481

High

477560

MYO1
Myosin-1

1

2

High-throughput

0.481

High

548204

BIK1
Nuclear fusion protein BIK1

1

13

High-throughput

0.481

High

597139

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.481

High

646404

RAD53
Serine/threonine-protein kinase RAD53

1

2

Small-scale

0.481

High

665821

KPC1
Protein kinase C-like 1

1

2

High-throughput

0.481

High

735623

SMY1
Kinesin-related protein SMY1

1

7

High-throughput

0.481

High

738383

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.481

High

743865

YEF3
Uncharacterized protein YEL043W

1

1

High-throughput

0.481

High

757697

EDE1
EH domain-containing and endocytosis protein 1

1

18

High-throughput

0.481

High

779752

DYHC
Dynein heavy chain, cytoplasmic

1

1

High-throughput

0.481

High

796572

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

15

High-throughput

0.481

High

803351

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

17

High-throughput

0.481

High

809179

END3
Actin cytoskeleton-regulatory complex protein END3

1

18

High-throughput

0.481

High

809183

SNF7
Vacuolar-sorting protein SNF7

1

2

High-throughput

0.481

High

809184

LIS1
Nuclear distribution protein PAC1

1

8

High-throughput

0.481

High

809186

TSC11
Target of rapamycin complex 2 subunit TSC11

1

1

High-throughput

0.481

High

809189

BNR1
BNI1-related protein 1

1

3

High-throughput

0.481

High

809196

BUD27
Bud site selection protein 27

1

1

High-throughput

0.481

High

809201

HMS2
Probable transcription factor HMS2

1

1

High-throughput

0.481

High

809209

YG3A
Uncharacterized protein YGR130C

1

12

High-throughput

0.481

High

809214

CNM67
Chaotic nuclear migration protein 67

1

1

High-throughput

0.481

High

809224

VPS60
Vacuolar protein-sorting-associated protein 60

1

2

High-throughput

0.481

High

509551

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

13

High-throughput

0.479

High

509895

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

3

High-throughput

0.479

High

750332

ARPC4
Actin-related protein 2/3 complex subunit 4

1

1

High-throughput

0.479

High

798136

ARPC1
Actin-related protein 2/3 complex subunit 1

1

8

High-throughput

0.479

High

803117

ECM29
Proteasome component ECM29

1

3

High-throughput

0.479

High

809193

ARPC5
Actin-related protein 2/3 complex subunit 5

1

1

High-throughput

0.479

High

809200

ARP3
Actin-related protein 3

1

5

High-throughput

0.479

High

809213

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

High-throughput

0.479

High

809232

ARPC3
Actin-related protein 2/3 complex subunit 3

1

1

High-throughput

0.479

High

809241

ATG9
Autophagy-related protein 9

1

5

High-throughput

0.479

High

809192

YRB2
Ran-specific GTPase-activating protein 2

1

1

High-throughput

0.470

High

809181

MBO1
Gamma tubulin complex adapter SPC72

1

1

High-throughput

0.470

High

555251

RAD50
DNA repair protein RAD50

1

3

High-throughput

0.464

High

600686

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.460

High

672409

STE50
Protein STE50

1

0

High-throughput

0.460

High

781104

YKC3
Uncharacterized protein YKL023W

1

0

High-throughput

0.460

High

790319

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

0

High-throughput

0.460

High

790444

PAM1
Protein PAM1

1

0

High-throughput

0.460

High

797876

CENPU
Inner kinetochore subunit AME1

1

0

High-throughput

0.460

High

804890

LAM4
Membrane-anchored lipid-binding protein LAM4

1

0

High-throughput

0.460

High

807885

BFR1
Nuclear segregation protein BFR1

1

0

High-throughput

0.460

High

809197

SAC3
Nuclear mRNA export protein SAC3

1

0

High-throughput

0.460

High

809203

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.460

High

809215

AF9
Protein AF-9 homolog

1

0

High-throughput

0.460

High

809233

HOB2
Protein YPR117W

1

0

High-throughput

0.460

High

809234

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.460

High

809242

NYV1
Vacuolar v-SNARE NYV1

1

0

High-throughput

0.460

High

809244

GYP5
GTPase-activating protein GYP5

1

0

High-throughput

0.460

High

809246

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.460

High

809211

SPC98
Spindle pole body component SPC98

1

0

High-throughput

0.458

High

523963

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

544889

SSB1
Ribosome-associated molecular chaperone SSB1

1

9

High-throughput

0.445

High

739367

ZUO1
Zuotin

1

4

High-throughput

0.445

High

741588

HSP7F
Heat shock protein homolog SSE1

1

11

High-throughput

0.445

High

804162

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.445

High

809180

TCPB
T-complex protein 1 subunit beta

1

3

High-throughput

0.445

High

809216

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.445

High

602045

KAR3
Kinesin-like protein KAR3

1

5

High-throughput

0.439

High

777047

BDF1
Bromodomain-containing factor 1

1

3

High-throughput

0.439

High

780877

STB6
Protein STB6

1

1

High-throughput

0.439

High

794176

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

1

High-throughput

0.439

High

805324

ERP5
Protein ERP5

1

1

High-throughput

0.439

High

809182

HPH2
Protein HPH2

1

1

High-throughput

0.439

High

809190

NDC80
Kinetochore protein NDC80

1

18

High-throughput

0.439

High

809198

STB2
Protein STB2

1

1

High-throughput

0.439

High

809207

ERP6
Protein ERP6

1

1

High-throughput

0.439

High

809212

PRS10
26S proteasome subunit RPT4

1

9

High-throughput

0.439

High

809221

PRS8
26S proteasome regulatory subunit 8 homolog

1

5

High-throughput

0.439

High

809222

CENPP
Inner kinetochore subunit CTF19

1

1

High-throughput

0.439

High

809223

SPP1
COMPASS component SPP1

1

1

High-throughput

0.439

High

809229

GLU2B
Glucosidase 2 subunit beta

1

1

High-throughput

0.439

High

809230

TAF7
Transcription initiation factor TFIID subunit 7

1

1

High-throughput

0.439

High

809236

IMH1
Golgin IMH1

1

2

High-throughput

0.439

High

809237

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.439

High

809238

YP216
Putative ISWI chromatin-remodeling complex subunit YPL216W

1

1

High-throughput

0.439

High

809239

MDN1
Midasin

1

2

High-throughput

0.439

High

809250

HPH1
Protein HPH1

1

1

High-throughput

0.439

High

707107

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

809217

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.437

High

809219

H3
Histone H3

1

2

High-throughput

0.437

High

752264

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

736381

MET4
Transcriptional activator of sulfur metabolism MET4

2

0

High-throughput

0.310

High

674410

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.279

Low

395244

GCN4
General control transcription factor GCN4

1

0

High-throughput

0.269

Low

809204

KNL1
Outer kinetochore KNL1 complex subunit SPC105

1

0

High-throughput

0.269

Low

809228

KAR5
Nuclear fusion protein KAR5

1

0

High-throughput

0.265

Low

736976

CDC3
Cell division control protein 3

1

0

High-throughput

0.251

Low

749672

TYE7
Transcription factor TYE7

1

0

High-throughput

0.251

Low

800342

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.251

Low

809185

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.251

Low

809195

GZF3
Protein GZF3

1

0

High-throughput

0.251

Low

809199

YJE9
Uncharacterized protein YJL049W

1

0

High-throughput

0.251

Low

809202

SNAPN
Biogenesis of lysosome-related organelles complex 1 subunit SNN1

1

0

High-throughput

0.251

Low

809205

KXD1
Biogenesis of lysosome-related organelles complex 1 subunit KXD1

1

0

High-throughput

0.251

Low

809206

MPS2
Monopolar spindle protein 2

1

0

High-throughput

0.251

Low

809208

NNF2
Protein NNF2

1

0

High-throughput

0.251

Low

809226

SHE9
Sensitive to high expression protein 9, mitochondrial

1

0

High-throughput

0.251

Low

809227

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.251

Low

809235

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.251

Low

809240

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.251

Low

809243

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.251

Low

809245

ERP3
Protein ERP3

1

0

High-throughput

0.251

Low

809249

MPD2
Protein disulfide isomerase MPD2

1

0

High-throughput

0.251

Low

764074

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

794989

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025